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J Appl Physiol (October 4, 2002). doi:10.1152/japplphysiol.00746.2001
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Articles in PresS, published online ahead of print October 4, 2002
J Appl Physiol, 10.1152/jap.00746.2001
Submitted on July 18, 2001
Accepted on September 23, 2002

Acetazolamide reduces exercise capacity and increases leg fatigue under hypoxic conditions

Luke A Garske1, Michael G Brown1, and Stephen C Morrison1*

1 Department of Thoracic Medicine, Royal Brisbane Hospital, Brisbane, Queensland, Australia

* To whom correspondence should be addressed. E-mail: Stephen_Morrison{at}health.qld.gov.au.

Acetazolamide (Acz) is used at altitude to prevent acute mountain sickness but its effect on exercise capacity under hypoxic conditions is uncertain. Nine healthy males completed this double-blind randomised cross-over study. All subjects underwent incremental exercise to exhaustion with FIO2 of 0.13, hypoxic ventilatory responses (HVR), and hypercapnic ventilatory responses (HCVR) following Acz (500mg twice daily for 5 doses) and placebo. Maximum power of 203 (SD 38) W on Acz was less than the placebo value of 225 (40) W (P<0.01). At peak exercise arterialised capillary pH was lower and PO2 higher on Acz (P<0.01). Ventilation was 118.6 (20.0) L/min at the maximal power on Acz and 102.4 (20.7) at the same power on placebo (P<0.02), and Borg score for leg fatigue was increased on Acz (P<0.02) with no difference in Borg score for dyspnea. HCVR on Acz was greater (P<0.02), while HVR was unchanged. During hypoxic exercise, Acz reduced exercise capacity associated with increased perception of leg fatigue. Despite increased ventilation, dyspnea was not increased.




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