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J Appl Physiol (November 14, 2003). doi:10.1152/japplphysiol.00745.2003
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Submitted on July 17, 2003
Accepted on November 7, 2003

Caffeine ingestion does not impede the resynthesis of proglycogen and macroglycogen following prolonged exercise and carbohydrate supplementation in humans

Danielle S Battram1*, Jane Shearer1, Deb Robinson2, and Terry E Graham1

1 Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
2 Family Medicine, Guelph General Hospital, Guelph, Ontario, Canada

* To whom correspondence should be addressed. E-mail: dbattram{at}uoguelph.ca.

The purpose of this study was to examine the effects of caffeine (CAF) ingestion on pro- (PG) and macroglycogen (MG) resynthesis in 10 healthy males. Subjects completed 2 trials, consisting of a glycogen-depleting exercise while ingesting either CAF or placebo (PL) capsules. Throughout recovery biopsies were taken at 0 (exh), 30, 120 and 300 min, and 75g of carbohydrate was ingested at 0, 60, 120, 180, and 240 min. While CAF ingestion resulted in a higher blood glucose concentration and decreased glycogen synthase fractional velocity (GSFV)(p<=0.05), no effect was observed in either the amount or rate of PG and MG resynthesis. PG concentration increased significantly at each time point during recovery, while MG concentration remained unchanged until 120 min. The net rate of PG resynthesis was 115 mmol/kg dw/h during the first 30 min of recovery then significantly decreased by 62% throughout the remaining 4.5 hours of recovery. The net rate of MG resynthesis was 77% lower than the net rate of PG resynthesis during the first 30 min of recovery and remained constant throughout 5 hours of recovery despite increasing levels of insulin. In conclusion, CAF ingestion does not impede the resynthesis of PG or MG following an extensive depletion of muscle glycogen and with the provision of exogenous dietary carbohydrate.




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