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Articles in PresS, published online ahead of print December 13, 2002
J Appl Physiol, 10.1152/jap.00744.2002
Submitted on August 12, 2002
Accepted on December 10, 2002
1 Department of Internal Medicine, State University of Campinas, School of Medicine, Campinas, SP, Brazil
2 Department of Pathology, Triangulo Mineiro School of Medicine, Uberaba, MG, Brazil
* To whom correspondence should be addressed. E-mail: franchin{at}obelix.unicamp.br.
To investigate the effects of colchicine on left ventricular function and hypertrophy (LVH) of rats subjected to constriction of transverse aorta (TAoC), we evaluated SO (sham-operated, vehicle; n=25), SO-T (Sham-operated, colchicine 0.4 mg/kg bwt i.p daily; n=38), TAoC (vehicle; n=37) and TAoC-T (TAoC, colchicine; n=34) at 2nd, 6th and 15th day after surgery. Colchicine attenuated LVH of TAoC-T compared with TAoC rats, evaluated by: ratio between left and right ventricles mass (LVM/RVM), LV wall thickness and average diameter of cardiac myocytes. Systolic gradient across TAoC (~45 mmHg), LV systolic pressure (LVSP), LV end diastolic pressure and [+]dP/dt were comparable in TAoC-T and TAoC rats. However, the baseline and increases of LVSP/LVM and [+]dP/dt/LVM induced by phenylephrine infusion were greater in TAoC-T and SO-T compared with SO rats. Baseline and increases of [+]dP/dt/LVM were reduced in TAoC compared to SO rats. TAoC rats increased polymerized fraction of tubulin compared with SO, SO-T and TAoC-T rats. Our results indicate that colchicine treatment reduced LVH to pressure overload but preserved LV function.
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