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J Appl Physiol (October 4, 2002). doi:10.1152/japplphysiol.00737.2002
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Articles in PresS, published online ahead of print October 4, 2002
J Appl Physiol, 10.1152/jap.00737.2002
Submitted on August 9, 2002
Accepted on September 24, 2002

AEROBIC POWER DECLINES WITH AGING IN RAT SKELETAL MUSCLES PERFUSED AT MATCHED RATES OF CONVECTIVE O2 DELIVERY

Russell T Hepple1*, Jason L Hagen2, Daniel J Krause3, and Cory C Jackson2

1 Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada; Faculty of Medicine, University of Calgary, Calgary, AB, Canada
2 Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada
3 Faculty of Medicine, University of Calgary, Calgary, AB, Canada

* To whom correspondence should be addressed. E-mail: hepple{at}ucalgary.ca.

Although it is well established that VO2max declines from adulthood to old age, the role played by alterations in skeletal muscle is unclear. Specifically, because during whole body exercise reductions in convective O2 delivery to the working muscles from adulthood to old age compromise aerobic performance, this obscures the influence of alterations within the skeletal muscles. We sought to overcome this limitation using an in situ pump-perfused hindlimb preparation to permit matching of muscle convective O2 delivery in young adult (8 mo; muscle convective O2 delivery = 569 ± 42 µmol O2 × min-1 × 100g-1) and late middle aged (28-30 mo; 539 ± 62 µmol O2 × min-1 × 100g-1) Fischer 344 X Brown Norway F1 Hybrid rats. The distal hindlimb muscles were electrically stimulated for 4 min (60 tetani × min-1) and VO2max was determined. VO2max normalized to the contracting muscle mass was 22% lower in the 28-30 mo old (344 ± 17 µmol O2 × min-1 × 100 g-1) than the 8 mo old (441 ± 20 µmol O2 × min-1 × 100g-1; P < 0.05) rats. The flux through the electron transport chain complexes I-III was 45% lower in homogenates prepared from the plantaris muscles of the older animals. Coincident with these alterations, the tension at VO2max and lactate efflux were reduced in the 28-30 mo old animals, whereas the percent decline in tension was greater in the 28-30 mo old versus 8 mo old animals. Collectively, these results demonstrate that alterations within the skeletal muscles, such as a reduced mitochondrial oxidative capacity, contribute to the reduction in VO2max with aging.




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