Journal of Applied Physiology AJP: Endocrinology and Metabolism
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J Appl Physiol (November 1, 2002). doi:10.1152/japplphysiol.00732.2002
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Articles in PresS, published online ahead of print November 1, 2002
J Appl Physiol, 10.1152/jap.00732.2002
Submitted on August 7, 2002
Accepted on October 27, 2002

The QDR 4500A dual energy x-ray absorptiometer overestimates fat free mass compared to criterion methods

Frances A Tylavsky1*, Timothy G Lohman2, Barbara A Blunt3, Dale A Schoeller4, Thomas Fuerst5, Jane A Cauley6, Michael C Nevitt7, Marjolein Visser8, and Tamara B Harris9

1 Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA
2 Department of Physiology, University of Arizona, Tucson, AZ, USA
3 PPD Development, Inc, Austin,, TX, USA
4 Department of Nutritional Sciences, University of Wisconsin, Madison, WI, USA
5 Synarc, Inc., San Francisco, CA, USA
6 Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
7 Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA
8 Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, Netherlands Antilles
9 National Institute on Aging, National Institutes of Health, Bethesda, MD, USA

* To whom correspondence should be addressed. E-mail: ftylavsky{at}utmem.edu.

This study evaluated the accuracy with which the dual energy x-ray absorptiometer (Hologic QDR 4500A) measured fat free mass (FFM), fat mass (FM) and hydration of FFM. In a study of 58 men and women (ages 70-79) the QDR 4500A was found to provide a systematically higher estimate of FFMand lower estimate of FM than a 4-component model of body composition. A correction factor from this study was developed and applied to two other samples (N=13 and N=37). We found mean corrected levels of FFM and FM to be equivalent to that obtained by the 4-component model or total body water. In addition, the hydration of the corrected FFM was closer to the established hydration level in adult samples and that obtained from the 4-component model. These findings suggest that the current calibration of the fan beam system of the Hologic QDR 4500A provides an overestimate of FFM and underestimate of FM compared to reference methods.




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