The purpose of this study was to compare the effects of intermittent and continuous static exercise on muscle perfusion, perfusion heterogeneity, and oxygen extraction. Perfusion and oxygen uptake of quadriceps femoris muscle was measured in ten healthy men using positron emission tomography and ¹⁵O-H₂O and ¹⁵O-O₂ first during intermittent (intermittent10%) static exercise (10% of maximal static force, MSF) and thereafter during continuous (continuous5%) static exercise at the same tension-time level (5% of MSF). In four of these subjects, perfusion was measured during continuous (continuous10%) static exercise with 10% of MSF, instead of the second ¹⁵O-O₂ measurement. Muscle oxygen consumption was similar during intermittent10% and continuous5% but muscle perfusion was significantly higher during continuous5%. Consequently, muscle oxygen extraction fraction was lower during continuous5%. Perfusion was also more heterogeneous during continuous5%. When exercise intensity was doubled during continuous static exercise (from continuous5% to continuous10%), muscle perfusion increased markedly. These results suggest that continuous low-intensity static exercise decreases muscle oxygen extraction and increases muscle perfusion and its heterogeneity compared to intermittent static exercise at the same relative exercise intensity.