Journal of Applied Physiology
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J Appl Physiol (January 18, 2002). doi:10.1152/japplphysiol.00721.2001
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Articles in PresS, published online ahead of print January 18, 2002
J Appl Physiol, 10.1152/jap.00721.2001
Submitted on July 10, 2001
Accepted on January 3, 2002

Blood flow distribution within the airway wall

Elizabeth M Wagner1* and Robert H Brown1

1 Medicine, Johns Hopkins University, Baltimore, MD, USA

* To whom correspondence should be addressed. E-mail: wagnerem{at}jhmi.edu.

Altered perfusion of the bronchial mucosal plexus relative to the adventitial plexus may contribute to geometric changes in the airway wall and lumen. We studied bronchial perfusion distribution in sheep using fluorescent microspheres at baseline and during intrabronchial artery challenge with methacholine chloride(MCh; n=7). Additionally we measured airways resistance(Raw) during MCh with control or increased perfusion(n=9). Raw with MCh was significantly greater for high than control flow. Microspheres in histologic sections, lodged predominantly in the mucosa (60%) and this was not altered by MCh. However, more microspheres lodged in airways >1mm diameter during MCh and increased perfusion than MCh and control flow. In airways <=1mm, fewer microspheres lodged during control than increased flow. If the number of microspheres represents regional agonist access to airway smooth muscle, then the differences observed in Raw can be explained by the distribution of agonist. During challenge, there was greater MCh delivery to larger airways during increased flow and less delivery to smaller airways during control flow. The results demonstrate the effects of axial perfusion distribution on Raw.




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