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J Appl Physiol (February 20, 2004). doi:10.1152/japplphysiol.00717.2003
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Submitted on July 10, 2003
Accepted on February 9, 2004

Muscle sympathetic nerve activity during lower-body negative pressure is accentuated in heat stressed humans

Jian Cui1, Thad E Wilson1, and Craig G Crandall2*

1 Presbyterian Hospital of Dallas, Institute for Exercise and Environmental Medicine, Dallas, Texas, USA
2 Presbyterian Hospital of Dallas, Institute for Exercise and Environmental Medicine, Dallas, Texas, USA; University of Texas Southwestern Medical Center, Department of Internal Medicine, Dallas, Texas, USA

* To whom correspondence should be addressed. E-mail: CraigCrandall{at}texashealth.org.

The purpose of this project was to test the hypothesis that increases in muscle sympathetic nerve activity (MSNA) during an orthostatic challenge is attenuated in heat stressed individuals. To accomplish this objective, MSNA was measured during graded lower-body negative pressure (LBNP) in 9 subjects under normothermic and heat stressed conditions. Progressive LBNP was applied at -3, -6, -9, -12, -15, -18, -21, and -40 mmHg for 2 min per stage. Whole-body heating caused significant increases in sublingual temperature, skin blood flow, sweat rate, heart rate, and MSNA (all P<0.05), but not mean arterial blood pressure (P>0.05). Progressive LBNP induced significant increases in MSNA in both thermal conditions. However, during the heat stress trial increases in MSNA at LBNP levels higher than -9 mmHg were greater when compared to during the same LBNP levels in normothermia (all P<0.05). These data suggest that the increase in MSNA to orthostatic stress is not attenuated but rather accentuated in heat stressed humans.




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