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J Appl Physiol (October 18, 2002). doi:10.1152/japplphysiol.00710.2002
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Articles in PresS, published online ahead of print October 18, 2002
J Appl Physiol, 10.1152/jap.00710.2002
Submitted on July 31, 2002
Accepted on October 8, 2002

Porcine Specific Hemoglobin Saturation Measurements

Richard Serianni1, Jed Barash1, Timothy Bentley2, Pushpa Sharma1, John L Fontana1, Darin Via1, Joachim Duhm3, Rolf Bunger4, and Paul D Mongan1*

1 Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
2 Walter Reed Army Institute of Research, Silver Spring, MD, USA
3 Department of Physiology, Universityof Munich, Munich, Germany
4 Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA

* To whom correspondence should be addressed. E-mail: pmongan{at}usuhs.mil.

The determination of oxygen consumption using arterio-venous oxygen content differences is dependent on accurate oxyhemoglobin saturation measurements. Because swine are a common experimental species, we describe the validation of co-oximeter for porcine specific oxyhemoglobin saturation. After developing a non-linear mathematical model of the porcine oxyhemoglobin saturation curve, 366 porcine oxyhemoglobin saturation determinations were made with a calibrated blood gas analyzer and a porcine specific co-oximeter. There was a high degree of correlation with minimal variability (r2 = 0.99, SEest = 5.2%) between the mathematical model and the porcine specific co-oximeter measurements. Bland-Altman comparison showed that the co-oximeter measurements were biased slightly lower (-0.4 vol%) and the limits of agreement (± 2SD) were 0.7 and -1.5 vol%. This is in contrast to a 10-20 vol% error if human specific methods were used. The results show excellent agreement between the nonlinear model and co-oximeter for porcine specific oxyhemoglobin saturation measurements. In contrast, comparison of the porcine specific oxyhemoglobin saturations with saturations obtained using human methods highlights the necessity of species-specific measurement methodology.




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