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J Appl Physiol (February 15, 2002). doi:10.1152/japplphysiol.00705.2001
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Articles in PresS, published online ahead of print February 15, 2002
J Appl Physiol, 10.1152/jap.00705.2001
Submitted on July 6, 2001
Accepted on February 11, 2002

Chronic hyperbaric exposure activates proinflammatory mediators in man

Anders M Ersson1*, Maria Walles2, Kjell Ohlsson2, and Anders Ekholm3

1 Department of Anaesthesiology, Malmoe General Hosptial, University Hospital, Malmo, Sweden
2 Department of Surgical Pathophysiology, Malmo General Hospital, University of Lund, Malmo, Sweden
3 Department of Anaesthesia, Ringerike Hospital, Honefoss, Norway

* To whom correspondence should be addressed. E-mail: familjen.ersson{at}spray.se.

Decompression illness(DCI) is an illness affecting divers subjected to reductions in ambient pressure. Beside a mechanical explanation to DCI, an inflammatory mechanism has been suggested. In this study levels of IL-8, IL-6, IL-1ra, SLPI and NGAL were measured in divers before and after a two-month period of daily diving. The divers were military conscripts and completed their diving period with no clinical symptoms of DCI. We found no change in IL-6 and IL1-ra, but an increase in IL-8 and NGAL together with a decrease in SLPI levels. The findings are suggestive of an inflammatory activation. This activation is not severe as no changes in IL-6 or IL-1ra were found. The increase in NGAL and IL-8 levels were interpreted as a sign of leukocyte activation. The decreased SLPI levels suggests an influence on the inflammatory defense mechanism. All in all the findings of this study show a compensated activation of the inflammatory defense mechanism without loss of homeostasis of the inflammatory system.






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