| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Articles in PresS, published online ahead of print November 16, 2001
J Appl Physiol, 10.1152/jap.00697.2001
Submitted on July 6, 2001
Accepted on November 5, 2001
1 Vascular Biology program, Lawson Health Research Institute, London, Ontario, Canada; Physiology, The Universtity of Western Ontario, London, Ontario, Canada; Medicine, The Universtity of Western Ontario, London, Ontario, Canada
2 Medicine, The Universtity of Western Ontario, London, Ontario, Canada
3 Chemistry, The Universtity of Western Ontario, London, Ontario, Canada
4 Vascular Biology program, Lawson Health Research Institute, London, Ontario, Canada
5 Chemistry, The Universtity of Western Ontario, London, Ontario, Canada; Obstetrics & Gyneacology, The Universtity of Western Ontario, London, Ontario, Canada
6 Obstetrics & Gyneacology, The Universtity of Western Ontario, London, Ontario, Canada; Biochemistry, The Universtity of Western Ontario, London, Ontario, Canada; Vascular Biology program, Lawson Health Research Institute, London, Ontario, Canada
* To whom correspondence should be addressed. E-mail: rveldhui{at}julian.uwo.ca.
Mechanical ventilation is an essential but potentially harmful therapeutic intervention for patients with acute lung injury. The objective of this study was to investigate the effects of mechanical ventilation on surfactant large aggregates (LA) structure and function. Isolated rat lungs were randomized to either a nonventilated control group, a relatively noninjuriously ventilated group (1hr, tidal volume 10ml/kg, 3cm PEEP) or an injuriously ventilated group (1hr, 20ml/kg, 0cm PEEP). Injurious ventilation resulted in significantly decrease lung compliance compared to the other two groups. LA structure, as determined by electronmicroscopy, revealed that LA from the injurious group had significantly lower amounts of organized lipid-protein structures compared to LA obtained from the other groups. Analysis of the biophysical properties using a captive bubble surfactometer demonstrated that the adsorption and surface tension reduction was significantly impaired with LA from the injuriously ventilated lungs. We conclude that the injurious mechanical ventilation impairs LA function and that this impairment is associated with significant morphological alterations.
This article has been cited by other articles:
|
|
 |
|
  A. A. Maruscak, D. W. Vockeroth, B. Girardi, T. Sheikh, F. Possmayer, J. F. Lewis, and R. A. W. Veldhuizen Alterations to surfactant precede physiological deterioration during high tidal volume ventilation Am J Physiol Lung Cell Mol Physiol, May 1, 2008; 294(5): L974 - L983. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Yamashita, A. Forbes, J. M. Tessolini, L.-J. Yao, J. F. Lewis, and R. A. W. Veldhuizen Protective effects of elevated endogenous surfactant pools to injurious mechanical ventilation Am J Physiol Lung Cell Mol Physiol, April 1, 2008; 294(4): L724 - L732. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. C. Bailey, A. A. Maruscak, A. Petersen, S. White, J. F. Lewis, and R. A. W. Veldhuizen Physiological effects of oxidized exogenous surfactant in vivo: effects of high tidal volume and surfactant protein A Am J Physiol Lung Cell Mol Physiol, October 1, 2006; 291(4): L703 - L709. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Hubmayr Ventilator-induced lung injury without biotrauma? J Appl Physiol, August 1, 2005; 99(2): 384 - 385. [Full Text] [PDF]
|
|
|
|
 |
|
 N. E. Vlahakis and R. D. Hubmayr Cellular Stress Failure in Ventilator-injured Lungs Am. J. Respir. Crit. Care Med., June 15, 2005; 171(12): 1328 - 1342. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Panda, K. Nag, R. R. Harbottle, K. Rodriguez-Capote, R. A. W. Veldhuizen, N. O. Petersen, and F. Possmayer Effect of Acute Lung Injury on Structure and Function of Pulmonary Surfactant Films Am. J. Respir. Cell Mol. Biol., May 1, 2004; 30(5): 641 - 650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. P. A. Rasaiah, J. L. Malloy, J. F. Lewis, and R. A. W. Veldhuizen Early surfactant administration protects against lung dysfunction in a mouse model of ARDS Am J Physiol Lung Cell Mol Physiol, May 1, 2003; 284(5): L783 - L790. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
