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1 School of Science and the Environment, Coventry University, Coventry, United Kingdom
2 Department of Biology, University of Antwerp, Antwerp, Belgium
3 School of Biology, University of Leeds, Leeds, United Kingdom
* To whom correspondence should be addressed. E-mail: r.james{at}coventry.ac.uk.
The effects of both 10 mM (high) and 70 µM (physiologically relevant) caffeine concentrations on force, work output and power output of isolated mouse extensor digitorum longus (EDL) and soleus muscles were investigated in vitro during recovery from fatigue at 35°C. Muscle performance during recovery from fatigue was monitored by regularly subjecting the muscle to a series of cyclical work loops. Force, work and power output during shortening were significantly higher following treatment with 10 mM caffeine, probably as a result of increased calcium release from the sarcoplasmic reticulum. However, the work required to re-lengthen the muscle also increased in the presence of 10 mM caffeine. This was due to a slowing of relaxation and an increase in muscle stiffness. The combined effect of increased work output during shortening and increased work input during lengthening had different effects on the two muscles. Net power output in mouse soleus muscle decreased as a result of 10 mM caffeine exposure, whereas the net power output of the EDL muscle showed a transient, significant increase. 70 µM caffeine had no significant effect on force, work or power output of EDL or soleus muscles, suggesting that the plasma concentrations found when caffeine is used to enhance performance in human athletes, might not directly affect the contractile performance of fatigued skeletal muscle.
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