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1 Dipartimento di Scienze e Tecnologie Biomediche, University of Milano, Segrate, MI, Italy
2 Istituto di Bioimmagini e Fisiologia Molecolare, Consiglio Nazionale delle Ricerche, Segrate, MI, Italy
3 Dipartimento di Scienze e Tecnologie Biomediche, University of L'Aquila, L'Aquila, Italy
* To whom correspondence should be addressed. E-mail: Bruno.Grassi{at}unimi.it.
Near Infrared Spectroscopy (NIRS) was utilized to gain insights into the kinetics of oxidative metabolism during exercise transitions. Ten untrained young males were tested on a cycloergometer during transitions from unloaded pedaling to 5-min constant-load exercise below (<VT) or above (>VT) the ventilatory threshold. Vastus lateralis oxygenation was determined by NIRS, and pulmonary VO2 was determined breath-by-breath. Changes in deoxygenated hemoglobin + myoglobin concentration (
[deoxy(Hb+Mb)]) were taken as a muscle oxygenation index. At the transition, [deoxy(Hb+Mb)] was unmodified (time delay, TD) for 8.9 ± 0.5 s (<VT) or 6.4 ± 0.9 s (>VT) (both significantly different from 0), and then increased following a monoexponential function (time constant, 
, 8.5 ± 0.9 s for <VT, 7.2 ± 0.7 s for >VT). For >VT a slow component of [deoxy(Hb+Mb)] on-kinetics was observed in 9 out of 10 subjects after 75.0 ± 14.0 s of exercise. A significant correlation was described between the mean response time (MRT = TD+) of the primary component of [deoxy(Hb+Mb)] on-kinetics and the of the primary component of the pulmonary VO2 on-kinetics. The constant muscle oxygenation during the initial phase of the on- transition indicates a tight coupling between O2 delivery and O2 utilization increases. The lack of a drop in muscle oxygenation at the transition suggests adequacy of O2 availability in relation to needs.
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