Journal of Applied Physiology AJP: Endocrinology and Metabolism
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J Appl Physiol (February 14, 2003). doi:10.1152/japplphysiol.00688.2002
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Submitted on July 26, 2002
Accepted on January 23, 2003

CT-Based Assessment of Regional Pulmonary Microvascular Blood Flow Parameters

Chulho Won1, Deokiee Chon1, Jehangir Tajik1, Binh Q Tran1, Gordon B Robinswood1, Kenneth C Beck1, and Eric A Hoffman1*

1 Department of Radiology and Biomedical Engineering, University of Iowa, Iowa City, IA, USA

* To whom correspondence should be addressed. E-mail: eric-hoffman{at}uiowa.edu.

To determine regional pulmonary microvascular mean transit times (MTT), we used ECG-gated x-ray CT imaging to follow bolus radiopaque contrast material through the lungs in anesthetized animals (7 dogs and 1 pig, prone and supine). By deconvolution / reconvolution of regional time-attenuation curves obtained from parenchyma and large lobar arteries, we estimated the microvascular residue function and thus reconstituted the regional microvascular time-attenuation curves and thus regional microvascular MTTs. The mean microvascular MTT in the supine and prone postures were 3.94±1.0 and 3.40±0.84 (MEAN±SD), respectively. The dependent-nondependent vertical gradient of MTT was greater in the supine [slope=0.25±0.10 (mean±SD); p<.001 (t-test)] than in the prone posture. [-0.03±0.06 in 6 of 8 animals; two outliers had positive slopes.] In both postures there was a trend towards faster transit times in the dorsal-basal lung region in 6 of the 8 animals, suggesting gravity-independent higher vascular conductance dorso-caudally. We conclude that deconvolution methods, in association with ECG-gated high speed x-ray CT, can provide insights into regional heterogeneity of pulmonary microvascular MTT in vivo.




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