Journal of Applied Physiology Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Appl Physiol (April 13, 2006). doi:10.1152/japplphysiol.00684.2005
This Article
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
101/2/492    most recent
00684.2005v2
00684.2005v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Martin, E. A.
Right arrow Articles by Joyner, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Martin, E. A.
Right arrow Articles by Joyner, M. J.
Submitted on June 9, 2005
Accepted on March 29, 2006

Bimodal Distribution of Vasodilator Responsiveness to Adenosine Due to Difference in Nitric Oxide Component: Implications for Exercise Hyperemia

Elizabeth A. Martin1*, Wayne T Nicholson1, Nisha Charkoudian1, and Michael J. Joyner1

1 Anesthesiology, Mayo College of Medicine, Rochester, Minnesota, United States; Physiology and Biomedical Engineering, Mayo College of Medicine, Rochester, Minnesota, United States

* To whom correspondence should be addressed. E-mail: martin.elizabeth2{at}mayo.edu.

To gain insight into the role of adenosine in exercise hyperemia, we compared forearm vasodilation induced by intra-arterial infusion of three doses of adenosine (ADO) to vasodilation during three workloads of handgrip exercise in 27 human subjects. We measured forearm blood flow using Doppler ultrasound and calculated forearm vascular conductance (FVC). We found that about half of the subjects demonstrated robust vasodilator responsiveness to both ADO infusion and exercise, and the other half demonstrated blunted vasodilator responsiveness to ADO infusion compared to exercise. In 15 subjects ("ADO responders"), the change in FVC above baseline (ml min-1 100 mmHg-1) was 209±33, 419±57, 603±75 for the low, medium, and high doses of ADO, respectively, and 221±35, 413±54, 582±70 for the low, medium, and high exercise workloads, respectively. In the other 12 subjects ("ADO non-responders"), the change in FVC above baseline was 102±36, 113±42, 151±54 for the low, medium, and high doses of ADO, respectively (P < 0.05 vs. ADO responders), whereas exercise hyperemia was not different from ADO responders (P > 0.05). Furthermore, infusion of NG-monomethyl-L-arginine (L-NMMA) blunted vasodilator responses to ADO infusion only in ADO responders (P < 0.01 vs. post-L-NMMA) and had no effect on exercise in either group. Responses to reactive hyperemia were not different between subgroups. We conclude that vasodilator responsiveness to ADO exhibits a bimodal distribution among human subjects involving differences in the contribution of nitric oxide to ADO-mediated vasodilation. Finally, our data support the concept that neither ADO nor nitric oxide is obligatory for exercise hyperemia.




This article has been cited by other articles:


Home page
 HypertensionHome page
S. P. Mortensen, M. Nyberg, P. Thaning, B. Saltin, and Y. Hellsten
Adenosine Contributes to Blood Flow Regulation in the Exercising Human Leg by Increasing Prostaglandin and Nitric Oxide Formation
Hypertension, June 1, 2009; 53(6): 993 - 999.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
C. J. Ray and J. M. Marshall
Elucidation in the rat of the role of adenosine and A2A-receptors in the hyperaemia of twitch and tetanic contractions
J. Physiol., April 1, 2009; 587(7): 1565 - 1578.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Shibasaki, D. A. Low, S. L. Davis, and C. G. Crandall
Nitric oxide inhibits cutaneous vasoconstriction to exogenous norepinephrine
J Appl Physiol, November 1, 2008; 105(5): 1504 - 1508.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
J. E. Sharman, C. M. McEniery, R. Campbell, P. Pusalkar, I. B. Wilkinson, J. S. Coombes, and J. R. Cockcroft
Nitric Oxide Does Not Significantly Contribute to Changes in Pulse Pressure Amplification During Light Aerobic Exercise
Hypertension, April 1, 2008; 51(4): 856 - 861.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. M. Marshall
The roles of adenosine and related substances in exercise hyperaemia
J. Physiol., September 15, 2007; 583(3): 835 - 845.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D. S. Battram, T. E. Graham, and F. Dela
Caffeine's impairment of insulin-mediated glucose disposal cannot be solely attributed to adrenaline in humans
J. Physiol., September 15, 2007; 583(3): 1069 - 1077.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
E. A. Martin, W. T. Nicholson, T. B. Curry, J. H. Eisenach, N. Charkoudian, and M. J. Joyner
Adenosine transporter antagonism in humans augments vasodilator responsiveness to adenosine, but not exercise, in both adenosine responders and non-responders
J. Physiol., February 15, 2007; 579(1): 237 - 245.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. A. Martin, W. T. Nicholson, J. H. Eisenach, N. Charkoudian, and M. J. Joyner
Influences of adenosine receptor antagonism on vasodilator responses to adenosine and exercise in adenosine responders and nonresponders
J Appl Physiol, December 1, 2006; 101(6): 1678 - 1684.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1948 by the American Physiological Society.