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J Appl Physiol (October 19, 2006). doi:10.1152/japplphysiol.00683.2006
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Submitted on June 19, 2006
Accepted on October 11, 2006

Differential activation among five human inspiratory motoneuron pools during tidal breathing

Julian Peter Saboisky1, Robert B Gorman2, Andre De Troyer3, Simon Gandevia4*, and Jane E Butler2

1 Prince of Wales Medical Research Institute, Sydney, New South Wales, Australia
2 Prince of Wales Medical Research Institute, Randwick, New South Wales, Australia
3 Chest Service, Erasme University Hospital, Brussels, Belgium
4 Prince of Wales Medical Research Institute, Randwick, Sydney, New South Wales, Australia

* To whom correspondence should be addressed. E-mail: s.gandevia.jap{at}unsw.edu.au.

Neural drive to inspiratory pump muscles is increased under many pathological conditions. This study determined for the first time how neural drive is distributed to five different human inspiratory pump muscles during tidal breathing. The discharge of single motor units (n=280) from 5 healthy subjects in the diaphragm, scalene, 2nd parasternal intercostal, 3rd dorsal external intercostal and 5th dorsal external intercostal was recorded with needle electrodes. All units increased their discharge during inspiration, but 41 (15%) discharged tonically throughout expiration. Motor unit populations from each muscle differed in the timing of their activation and in the discharge rates of their motor units. Relative to the onset of inspiratory flow, the earliest recruited muscles were the diaphragm and 3rd dorsal external intercostal (mean onset for the population after 26% and 29% of inspiratory time [TI]). The 5th dorsal external intercostal muscle was recruited later (43% TI; p<0.05). Compared to the other inspiratory muscles, units in the diaphragm and 3rd dorsal external intercostal had the highest onset (7.7Hz and 7.1Hz, respectively) and peak firing frequencies (12.6Hz, 11.9Hz, both p<0.05). There was a unimodal distribution of recruitment times of motor units in all muscles. Neural drive to human inspiratory pump muscles differs in timing, strength and distribution, presumably to achieve efficient ventilation.




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