Journal of Applied Physiology Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Appl Physiol (August 10, 2006). doi:10.1152/japplphysiol.00681.2006
This Article
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
102/1/37    most recent
00681.2006v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gao, L.
Right arrow Articles by Wang, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gao, L.
Right arrow Articles by Wang, W.
Submitted on June 16, 2006
Accepted on August 7, 2006

Cardiac Sympathetic Afferent Stimulation Augments the Arterial Chemoreceptor Reflex in Anesthetized Rats

Lie Gao1, Yan-Xia Pan1, Weizhong Wang1, Yu-Long Li1, Harold D. Schulz1, Irving H. Zucker1, and Wei Wang1*

1 Department of Cellular and Integrative Physiology, University of Nebraska College of Medicine, Omaha, Nebraska, United States

* To whom correspondence should be addressed. E-mail: weiwang{at}unmc.edu.

Chronic heart failure (CHF) is well known to be associated with both an enhanced chemoreceptor reflex and an augmented cardiac "sympathetic afferent reflex" (CSAR). The augmentation of the CSAR may play an important role in the enhanced chemoreceptor reflex in the CHF state because the same central areas are involved in the sympathetic outputs of both reflexes. We determined if chemical and electrical stimulation of the CSAR augments chemoreceptor reflex function in normal rats. Under anesthesia, renal sympathetic nerve activity (RSNA) and mean arterial pressure (MAP) were recorded. The chemoreceptor reflex was tested by unilateral intra carotid artery bolus injection of potassium cyanide (KCN) and nicotine. We found that: (1) left ventricular epicardial application of capsaicin increased the pressor responses and the RSNA responses to chemoreflex activation induced by both KCN and nicotine; (2) when the central end of the left cardiac sympathetic nerve was electrically stimulated, both the pressor and the RSNA responses to chemoreflex activation induced by KCN were increased; (3) pre-treatment with intracerebroventricular (icv) injection of losartan (500 nmol) completely prevented the enhanced chemoreceptor reflex induced by electrical stimulation of the cardiac sympathetic nerve; and (4) Bilateral microinjection of losartan (250 pmol) into the nucleus tractus solitarii (NTS) completely abolished the enhanced chemoreceptor reflex by epicardial application of capsaicin. These results suggest that both the chemical and electrical stimulation of the CSAR augments chemoreceptor reflex and that central Ang II, specially located in the NTS, plays a major role in these reflex interactions.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
V. M. Pulgar, J. K.-s. Hong, J. A. Jessup, A. G. Massmann, D. I. Diz, and J. P. Figueroa
Mild chronic hypoxemia modifies expression of brain stem angiotensin peptide receptors and reflex responses in fetal sheep
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2009; 297(2): R446 - R452.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Y.-L. Li, Y. Ding, C. Agnew, and H. D. Schultz
Exercise training improves peripheral chemoreflex function in heart failure rabbits
J Appl Physiol, September 1, 2008; 105(3): 782 - 790.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. K. Stickland and J. D. Miller
The best medicine: exercise training normalizes chemosensitivity and sympathoexcitation in heart failure
J Appl Physiol, September 1, 2008; 105(3): 779 - 781.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
W.-Z. Wang, L. Gao, H.-J. Wang, I. H. Zucker, and W. Wang
Interaction between cardiac sympathetic afferent reflex and chemoreflex is mediated by the NTS AT1 receptors in heart failure
Am J Physiol Heart Circ Physiol, September 1, 2008; 295(3): H1216 - H1226.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Y. Ding, Y.-L. Li, and H. D. Schultz
Downregulation of carbon monoxide as well as nitric oxide contributes to peripheral chemoreflex hypersensitivity in heart failure rabbits
J Appl Physiol, July 1, 2008; 105(1): 14 - 23.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
W.-Z. Wang, L.-G. Wang, L. Gao, and W. Wang
Contribution of AMPA/kainate receptors in the rostral ventrolateral medulla to the hypotensive and sympathoinhibitory effects of clonidine
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1232 - R1238.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
M. K. Stickland, J. D. Miller, C. A. Smith, and J. A. Dempsey
Carotid Chemoreceptor Modulation of Regional Blood Flow Distribution During Exercise in Health and Chronic Heart Failure
Circ. Res., May 11, 2007; 100(9): 1371 - 1378.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Y.-H. Du and A. F. Chen
A "love triangle" elicited by electrochemistry: complex interactions among cardiac sympathetic afferent, chemo-, and baroreflexes
J Appl Physiol, January 1, 2007; 102(1): 9 - 10.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1948 by the American Physiological Society.