Journal of Applied Physiology Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Appl Physiol (September 6, 2002). doi:10.1152/japplphysiol.00676.2002
This Article
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
93/6/2122    most recent
00676.2002v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kavdia, M.
Right arrow Articles by Popel, A. S
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kavdia, M.
Right arrow Articles by Popel, A. S

Articles in PresS, published online ahead of print September 6, 2002
J Appl Physiol, 10.1152/jap.00676.2002
Submitted on July 24, 2002
Accepted on August 30, 2002

Theoretical Analysis of the Effects of Blood Substitute Affinity and Cooperativity on Organ Oxygen Transport

Mahendra Kavdia1*, Roland N Pittman2, and Aleksander S Popel1

1 Department of Biomedical Engineering, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
2 Department of Physiology, Virginia Commonwealth University, Richmond, VA, USA

* To whom correspondence should be addressed. E-mail: kavdia{at}bme.jhu.edu.

Hemoglobin-based oxygen carriers (HBOCs), which are developed as an alternate to blood transfusion, provide oxygen (O2) delivery. At present, there is no model to predict the O2 transport for an RBC-HBOC mixture on a whole organ basis. Based on the first principles of mass balance, a model of O2 transport for an organ was derived to calculate mixed venous oxygen partial pressure (Pv) for a given inlet arterial oxygen partial pressure (Pa), blood flow and oxygen consumption. The model was validated using several in vivo animal studies on HBOC administration for wide range of HBOC oxygen binding parameters and predicted Pv for various Pa in the same species. The model was also used to predict the effect of HBOC affinity and cooperativity on Pv for humans. The results indicate that Pv can be increased at a constant blood flow/oxygen consumption ratio by reducing the affinity of HBOC for normoxia and mild hypoxia, however a high affinity HBOC would be more efficient in maintaining higher Pv for severe hypoxia (Pa<40 mmHg).




This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Rebel, S. Cao, H. Kwansa, S. Dore, E. Bucci, and R. C. Koehler
Dependence of acetylcholine and ADP dilation of pial arterioles on heme oxygenase after transfusion of cell-free polymeric hemoglobin
Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1027 - H1037.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. O. Dull, B. J. DeWitt, R. Dinavahi, L. Schwartz, C. Hubert, N. Pace, and C. Fronticelli
Quantitative assessment of hemoglobin-induced endothelial barrier dysfunction
J Appl Physiol, November 1, 2004; 97(5): 1930 - 1937.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
G. M. T. Hare, K. M. Hum, S. Y. Kim, A. Barr, A. J. Baker, and C. D. Mazer
Increased Cerebral Tissue Oxygen Tension After Extensive Hemodilution with a Hemoglobin-Based Oxygen Carrier
Anesth. Analg., August 1, 2004; 99(2): 528 - 535.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. Contaldo, S. Schramm, R. Wettstein, H. Sakai, S. Takeoka, E. Tsuchida, M. Leunig, A. Banic, and D. Erni
Improved oxygenation in ischemic hamster flap tissue is correlated with increasing hemodilution with Hb vesicles and their O2 affinity
Am J Physiol Heart Circ Physiol, August 7, 2003; 285(3): H1140 - H1147.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1966 by the American Physiological Society.