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J Appl Physiol (September 6, 2002). doi:10.1152/japplphysiol.00676.2002
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Articles in PresS, published online ahead of print September 6, 2002
J Appl Physiol, 10.1152/jap.00676.2002
Submitted on July 24, 2002
Accepted on August 30, 2002

Theoretical Analysis of the Effects of Blood Substitute Affinity and Cooperativity on Organ Oxygen Transport

Mahendra Kavdia1*, Roland N Pittman2, and Aleksander S Popel1

1 Department of Biomedical Engineering, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
2 Department of Physiology, Virginia Commonwealth University, Richmond, VA, USA

* To whom correspondence should be addressed. E-mail: kavdia{at}bme.jhu.edu.

Hemoglobin-based oxygen carriers (HBOCs), which are developed as an alternate to blood transfusion, provide oxygen (O2) delivery. At present, there is no model to predict the O2 transport for an RBC-HBOC mixture on a whole organ basis. Based on the first principles of mass balance, a model of O2 transport for an organ was derived to calculate mixed venous oxygen partial pressure (Pv) for a given inlet arterial oxygen partial pressure (Pa), blood flow and oxygen consumption. The model was validated using several in vivo animal studies on HBOC administration for wide range of HBOC oxygen binding parameters and predicted Pv for various Pa in the same species. The model was also used to predict the effect of HBOC affinity and cooperativity on Pv for humans. The results indicate that Pv can be increased at a constant blood flow/oxygen consumption ratio by reducing the affinity of HBOC for normoxia and mild hypoxia, however a high affinity HBOC would be more efficient in maintaining higher Pv for severe hypoxia (Pa<40 mmHg).




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