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J Appl Physiol (December 21, 2001). doi:10.1152/japplphysiol.00675.2001
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Articles in PresS, published online ahead of print December 21, 2001
J Appl Physiol, 10.1152/jap.00675.2001
Submitted on June 29, 2001
Accepted on November 9, 2001

Correlation properties of tidal volume, end-tidal O2 and CO2 concentrations in healthy infants

Mateja Cernelc1, Bela Suki2, Benjamin Reinmann1, Graham L Hall1, and Urs Frey1*

1 Dept. of Pediatrics, University Hospital of Berne, Berne, BE, Switzerland
2 Dept. of Biomedical Engineering, Boston University, Boston, MA, USA

* To whom correspondence should be addressed. E-mail: urs.frey{at}insel.ch.

We investigated whether breath to breath fluctuations in tidal volume (Vt), and end-tidal O2 and CO2 exhibit long-range correlations and whether parameters describing the correlations can be used as a non-invasive descriptor of control of breathing. We measured Vt, end-tidal O2 and CO2 over 352 ± 104 breaths in 26 term, healthy, unsedated infants (Age ± SD: 36 ± 6 days) and calculated the detrended fluctuation function F(n). The F(n) of the breath to breath time series of Vt, O2 and CO2 revealed a linear increase with a breath number (n) on log-log plots with a slope {alpha} which was significantly different from 0.5 (=randomness) and thus consistent with scale-invariant behavior. Long-range correlations were stronger for O2 than for Vt and CO2. The F(n) of many individual signals exhibited a crossover behavior indicating that control mechanisms regulating fluctuations of Vt, O2 and CO2 may be different on different time scales. Thus, breathing has "a memory" up to at least 400 breaths that can be characterized by the simple indicator {alpha}.




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