Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Appl Physiol (October 26, 2001). doi:10.1152/japplphysiol.00672.2001
This Article
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
92/2/581    most recent
00672.2001v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Edelberg, J. M
Right arrow Articles by Christini, D. J
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Edelberg, J. M
Right arrow Articles by Christini, D. J

Articles in PresS, published online ahead of print October 22, 2001
J Appl Physiol, 10.1152/jap.00672.2001
Submitted on June 29, 2001
Accepted on October 12, 2001

Enhanced Myocyte-Based Biosensing of the Blood-Borne Signals Regulating Chronotropy

Jay M Edelberg1*, Jason T Jacobson2, David S Gidseg2, Lilong Tang2, and David J Christini3

1 Medicine, Weill Medical College of Cornell University, New York, New York, USA; Cell Biology, Weill Medical College of Cornell University, New York, New York, USA
2 Medicine, Weill Medical College of Cornell University, New York, New York, USA
3 Medicine, Weill Medical College of Cornell University, New York, New York, USA; Physiology and Biophysics, Weill Medical College of Cornell University, New York, New York, USA

* To whom correspondence should be addressed. E-mail: jme2002{at}mail.med.cornell.edu.

Biosensors play a critical role in the real-time determination of relevant functional physiological needs. However, typical in vivo biosensors only approximate endogenous function via the measurement of surrogate signals, and therefore may often lack a high degree of dynamic fidelity with physiologic requirements. To overcome this limitation we have developed an excitable tissue-based implantable biosensor approach exploiting the inherent electropotential input-output relationship of cardiac myocytes to measure the physiological regulatory inputs of chronotropic demand via the detection of blood-borne signals. Here we report the improvement of this application through the modulation of host-biosensor communication via the enhancement of vascularization of chronotropic complexes in mice. Moreover, in an effort to further improve translational applicability as well as molecular plasticity, we have advanced this approach by employing stem cell-derived cardiac myocyte aggregates in the place of whole cardiac tissue. Overall these studies demonstrate the potential of biologically-based biosensors to predict endogenous physiological dynamics and may facilitate the translation of this approach for in vivo monitoring.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. A. Klibansky, A. Chin, I. J. Duignan, and J. M. Edelberg
Synergistic targeting with bone marrow-derived cells and PDGF improves diabetic vascular function
Am J Physiol Heart Circ Physiol, April 1, 2006; 290(4): H1387 - H1392.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. V. Shmelkov, S. Meeus, N. Moussazadeh, P. Kermani, W. K. Rashbaum, S. Y. Rabbany, M. A. Hanson, W. J. Lane, R. St. Clair, K. A. Walsh, et al.
Cytokine Preconditioning Promotes Codifferentiation of Human Fetal Liver CD133+ Stem Cells Into Angiomyogenic Tissue
Circulation, March 8, 2005; 111(9): 1175 - 1183.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
J. M. Edelberg, L. Tang, K. Hattori, D. Lyden, and S. Rafii
Young Adult Bone Marrow-Derived Endothelial Precursor Cells Restore Aging-Impaired Cardiac Angiogenic Function
Circ. Res., May 31, 2002; 90 (10): e89 - e93.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2008 by the American Physiological Society.