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Articles in PresS, published online ahead of print January 4, 2002
J Appl Physiol, 10.1152/jap.00669.2001
Submitted on June 29, 2001
Accepted on December 18, 2001
1 Department of Sport Science, University of Aarhus, Arhus N, Denmark
2 Department of Physiology, University of Aarhus, Arhus C, Denmark
* To whom correspondence should be addressed. E-mail: ko{at}idraet.au.dk.
During prolonged exercise changes in the ionic milieu in and surrounding the muscle fibers may lead to fatigue or damage of the muscle, and thereby impair performance. In 10 male subjects, we investigated the effects of 100 km running on muscle and plasma electrolyte contents, muscle Na+-K+ pump content, and plasma concentrations of creatine kinase (CK) and lactate dehydrogenase (LDH). Following the completion of a 100 km run significant increases were found in plasma K+ (from 4.0 ± 0.1 to 5.5 ± 0.2 mM, P < 0.001), muscle Na+-K+ pump content (from 334 ± 11 to 378 ± 17 pmol/g, P < 0.05) and total muscle Ca++ content (from 0.84 ± 0.03 to 1.02 ± 0.04 µmol/g, P < 0.001). There was also a large increase in the plasma levels of the muscle specific enzymes CK and LDH reaching peak values at the end of the run and lasting several days after the run, indicating that a significant degree of muscle membrane leakage was present. The simultaneous occurrence of raised cellular Ca++ content and muscle muscle membrane leakage, supports the theory that Ca++ plays a role in the initiation of degenerative processes in muscles following severe exercise.
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