Limb vascular conductance responses to pharmacological and non-exercise vasodilator stimuli are generally augmented in women compared to men. In the present investigation we tested the hypothesis that exercise-induced vasodilator responses are also greater in women than men. Sixteen women and fifteen men (20-30 yr) with similar fitness and activity levels performed graded quadriceps exercise (supine, single leg knee extensions, 40 contractions/min) to maximal exertion. Active limb hemodynamics (left common femoral artery diameter and volumetric blood flow), heart rate (ECG) and beat-to-beat arterial blood pressure (MAP, radial artery tonometry) were measured during each 3-min workload (4.8 and 8 watts/stage for women and men, respectively). The hyperemic response to exercise (slope of femoral blood flow vs. workload) was greater (p< 0.01) in women as was femoral blood flow at workloads greater than 15 watts. The leg vasodilatory response to exercise (slope of calculated femoral vascular conductance vs. absolute workload) was also greater in women than in men (p < 0.01) due to the sex difference in hyperemia and the women’s lower MAP (~10-15 mmHg) at all workloads (p<0.05). The femoral artery dilated to a significantly greater extent in the women (~0.5 mm) than in the men (~0.01 mm) across all submaximal workloads. At maximal exertion, femoral vascular conductance was lower in the men (men, 18.0 ± 0.6 mL/min/mmHg; women, 22.6 ± 1.4 mL/min/mmHg; p < 0.01). Collectively, these findings suggest that the vasodilatory response to dynamic leg exercise is greater in young women vs. men.