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Articles in PresS, published online ahead of print November 1, 2002
J Appl Physiol, 10.1152/jap.00658.2002
Submitted on July 18, 2002
Accepted on October 28, 2002
1 Department of Medicine, Queen's University, Kingston, Ontario, Canada
* To whom correspondence should be addressed. E-mail: mf19{at}post.queensu.ca.
The oral and nasal contributions to inhaled ventilation were simultaneously quantified during sleep in ten healthy subjects (5M, 5F) aged 43 ± 5 years with normal nasal resistance (mean 2.0 ± 0.3 cmH2O/L/s), using a divided oral and nasal mask. Minute ventilation awake (5.9 ± 0.3 L/min) was higher than that during sleep (5.2 ± 0.3 L/min; p<0.0001) but there was no significant difference in minute ventilation between different sleep stages (p=0.44): stage 2 (5.3 ± 0.3 L/min), slow wave sleep (5.2 ± 0.2 L/min), REM sleep (5.2 ± 0.2 L/min). The oral fraction of inhaled ventilation during wakefulness (7.6 ± 4%) was not significantly different from that during sleep (4.3 ± 2%; mean difference 3.3%, 95% CI -2.1 to 8.8%, p=0.19), and no significant difference (p=0.14) in oral fraction was observed between different sleep stages: stage two 5.1 ± 2.8%, slow wave sleep 4.2 ± 1.8%, REM sleep 3.1 ± 1.7%. Thus, the inhaled oral fraction in normal subjects is small and does not change significantly with sleep stage.
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