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J Appl Physiol (October 18, 2002). doi:10.1152/japplphysiol.00656.2002
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Articles in PresS, published online ahead of print October 18, 2002
J Appl Physiol, 10.1152/jap.00656.2002
Submitted on July 17, 2002
Accepted on October 11, 2002

Hindlimb unloading has a greater effect on cortical compared to cancellous bone in mature female rats

Matthew R Allen1 and Susan A Bloomfield1*

1 Department of Health and Kinesiology, Texas A&M University, College Station, TX, USA

* To whom correspondence should be addressed. E-mail: sbloom{at}tamu.edu.

This study was designed to determine the effects of 28 days of hindlimb unloading (HU) on the mature female rat skeleton. In vivo proximal tibia bone mineral density (BMD) and geometry of HU and cage controls (CC) were measured using peripheral quantitative computed tomography (pQCT) on days 0 and 28. Post-sacrifice pQCT, histomorphometry, and mechanical testing were performed on tibiae and femora. After 28 days, HU animals had significantly higher daily food consumption (+ 39%) and lower serum estradiol levels (- 49%, p = 0.079) compared to CC. Proximal tibia bone mineral content and cortical bone area significantly declined over 28 days in HU animals (- 4.0 and 4.8%, respectively) while total and cancellous BMD were unchanged. HU animals had lower cortical bone formation rates and mineralizing surface at tibial mid-shaft, while differences in similar properties were not detected in cancellous bone of the distal femur. These results suggest that cortical bone, rather than cancellous bone, is more prominently affected by unloading in skeletally mature retired breeder female rats.




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