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J Appl Physiol (August 8, 2003). doi:10.1152/japplphysiol.00638.2003
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Submitted on June 19, 2003
Accepted on July 31, 2003

Changing expressions of cytochrome oxidase in various brain stem nuclei during postnatal development of rats: implications for sensitive periods

Qiuli Liu1 and Margaret T. Wong-Riley1*

1 Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA

* To whom correspondence should be addressed. E-mail: mwr{at}mcw.edu.

Previously, we reported that cytochrome oxidase (CO) activity in the rat pre-Botzinger complex (PBC) exhibited a plateau on postnatal days (P) 3-4 and a prominent decrease on P12. These changes were correlated with a concomitant reduction in the expression of glutamate and NMDAR1, and an increase in GABA, GABAB, GlyR, and GluR2. To determine if changes were limited to the PBC, the present study aimed at examining the expression of CO in a number of brain stem nuclei with or without known respiratory functions from P0 to P21 in rats: the ventrolateral subnucleus of the solitary tract nucleus (NTSVL), nucleus ambiguus (Amb), hypoglossal nucleus (XII), nucleus raphe obscurus (ROb), dorsal motor nucleus of the vagus nerve (DMNX), medial accessory olivary nucleus (IOma), spinal nucleus of the trigeminal nerve (SPV), and medial vestibular nucleus (MVe). Results indicated that in all of the brain stem nuclei examined, CO activity exhibited a general increase with age from P0 to P21, with MVe having the slowest rise. Notably, in all of the nuclei examined except for MVe, there was a plateau or decrease at P3-4 and a prominent rise-fall-rise pattern at P11-13, similar to that observed in the PBC. In addition, there was a fall-rise-fall pattern at P15-17 in these nuclei instead of a plateau pattern in the PBC. Our data suggest that the two postnatal periods with reduced CO activity, P3-4 and especially P12, may represent common sensitive periods for most of the brain stem nuclei with known or suspected respiratory control functions.




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