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1 Surgery, University of Texas Medical Branch, Galveston, TX, USA
2 Metabolism Unit, Shriners Burns Hospital, Galveston, TX, USA; Surgery, University of Texas Medical Branch, Galveston, TX, USA
* To whom correspondence should be addressed. E-mail: wdurham{at}bcm.tmc.edu.
The present study investigated the responses of leg glucose and protein metabolism during an acute bout of resistance exercise. Seven subjects (5M, 2F) were studied at rest and during a strenuous lower body resistance exercise regimen consisting of approximately 8 sets of 10 repetitions of leg press at ~75% 1 repetition maximum (1RM) and 8 sets of 8 repetitions of knee extensions at ~80% 1RM. L-[ring-2H5]phenylalanine was infused throughout the study for measurement of phenylalanine rates of appearance (Ra), disappearance (Rd), protein synthesis and protein breakdown across the leg. Femoral arterial and venous blood samples were collected at rest and during exercise for determination of leg blood flow, concentrations of glucose, lactate, alanine, glutamine, glutamate, leucine, and phenylalanine, and phenylalanine enrichments. Muscle biopsies were obtained at rest and immediately following exercise. Leg blood flow was nearly three times (P<0.009) higher and glucose uptake more than five times higher (P=0.009) during exercise than at rest. Leg lactate release was 86 times higher than rest during the exercise bout. Although whole body phenylalanine Ra, an indicator of whole body protein breakdown, was reduced during exercise, leg phenylalanine Ra, Rd, protein synthesis, and protein breakdown did not change. Arterial and venous alanine concentrations and glutamate uptake were significantly higher during exercise than at rest. We conclude that lower-body resistance exercise potently stimulates leg glucose uptake and lactate release. In addition, muscle protein synthesis is not elevated during a bout of resistance exercise.
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