| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Articles in PresS, published online ahead of print August 9, 2002
J Appl Physiol, 10.1152/jap.00631.2001
Submitted on June 19, 2001
Accepted on August 5, 2002
1 School of Physiotherapy and Exercise Sciences, Griffith University, Gold Coast, Queensland, Australia
2 Department of Biochemistry and Molecular Biology, The Australian National University, Canberra, ACT, Australia
3 Department of Physiology, Australian Institute of Sport, Canberra, ACT, Australia
4 Statistical Consulting Unit of the Graduate School, The Australian National University, Canberra, ACT, Australia
* To whom correspondence should be addressed. E-mail: rtelford{at}ausport.gov.au.
There is a wide body of literature reporting red cell hemolysis to occur following various forms of exercise. Whilst the trauma associated with footstrike is thought to be the major cause of hemolysis following running, its significance compared with hemolysis that results from other circulatory stresses on the red blood cell has not been thoroughly addressed. To investigate the significance of footstrike we measured the degree of hemolysis following one hour of running. To control for the potential effects of oxidative and circulatory stresses on the red blood cell, the same subjects cycled for one hour at equivalent oxygen uptake. Our subjects were ten male triathletes, who each completed two separate 1 hour sessions of running and cycling at 75% peak oxygen uptake (VO2 peak) performed in random order 1 week apart. Plasma free hemoglobin and serum haptoglobin concentrations were measured as indicators of hemolysis. We also measured methemoglobin as a percentage of total hemoglobin immediately post-exercise as an indicator of red cell oxidative stress. Plasma free hemoglobin increased after both running (P<0.01) and cycling (P<0.01), but the increase was 4-fold greater after running (P<0.01). This was reflected by a significant fall in haptoglobin 1 hour after the running trials while no significant changes occurred after cycling at any sample point. Methemoglobin increased 2-fold after both running and cycling (P<0.01) with no significant differences between modes of exercise. The present data indicate that whilst general circulatory trauma to the red blood cells associated with 1 hour of exercise at 75% VO2 max may result in some exercise-induced hemolysis, footstrike is the major contributor to hemolysis during running.
This article has been cited by other articles:
|
|
 |
|
  D. Tobal, A. Olascoaga, G. Moreira, M. Kurdian, F. Sanchez, M. Rosello, W. Alallon, F. G. Martinez, and O. Noboa Rust Urine after Intense Hand Drumming Is Caused by Extracorpuscular Hemolysis Clin. J. Am. Soc. Nephrol., July 1, 2008; 3(4): 1022 - 1027. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. V. Brugniaux, L. Schmitt, P. Robach, G. Nicolet, J.-P. Fouillot, S. Moutereau, F. Lasne, V. Pialoux, P. Saas, M.-C. Chorvot, et al. Eighteen days of "living high, training low" stimulate erythropoiesis and enhance aerobic performance in elite middle-distance runners J Appl Physiol, January 1, 2006; 100(1): 203 - 211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. K. Senturk, F. Gunduz, O. Kuru, G. Kocer, Y. G. Ozkaya, A. Yesilkaya, M. Bor-Kucukatay, M. Uyuklu, O. Yalcin, and O. K. Baskurt Exercise-induced oxidative stress leads hemolysis in sedentary but not trained humans J Appl Physiol, October 1, 2005; 99(4): 1434 - 1441. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R Akabas and K. R Dolins Micronutrient requirements of physically active women: what can we learn from iron? Am. J. Clinical Nutrition, May 1, 2005; 81(5): 1246S - 1251S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Wang, J. E. Tanus-Santos, C. D. Reiter, A. Dejam, S. Shiva, R. D. Smith, N. Hogg, and M. T. Gladwin Biological activity of nitric oxide in the plasmatic compartment PNAS, August 3, 2004; 101(31): 11477 - 11482. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Lasne, N. Crepin, M. Ashenden, M. Audran, and J. de Ceaurriz Detection of Hemoglobin-Based Oxygen Carriers in Human Serum for Doping Analysis: Screening by Electrophoresis Clin. Chem., February 1, 2004; 50(2): 410 - 415. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
