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J Appl Physiol (August 27, 2004). doi:10.1152/japplphysiol.00625.2004
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Submitted on June 18, 2004
Accepted on August 26, 2004

Inspiratory Flow in the nose: a model coupling flow and vasoerectile tissue distensibility

Redouane Fodil1, Lydia Brugel-Ribere2, Celine Croce1, Gabriela Sbirlea-Apiou3, Christian Larger4, Jean-francois Papon2, Christophe Delclaux5, Andre Coste2, Daniel Isabey1, and Bruno Louis1*

1 Physiopathologie et Therapeutique Respiratoire INSERM UMR 492, Creteil, France
2 Physiopathologie et Therapeutique Respiratoire INSERM UMR 492, Creteil, France; Service d ORL et de Chirurgie Cervico-Faciale, Centre Hospitalier Inter-Communal de Creteil, Creteil, France
3 Centre de Recherche Claude Delorme, Air Liquide, Jouy en Josas, France
4 Service de Physiologie - Explorations Fonctionnelles, Hopital Henri Mondor Assistance Publique Hopitaux de Paris, Creteil, France
5 Physiopathologie et Therapeutique Respiratoire INSERM UMR 492, Creteil, France; Service de Physiologie - Explorations Fonctionnelles, Hopital Henri Mondor Assistance Publique Hopitaux de Paris, Creteil, France

* To whom correspondence should be addressed. E-mail: bruno.louis{at}creteil.inserm.fr.

We have developed a discrete multisegmental model describing the coupling between inspiratory flow and nasal wall distensibility. This model is composed of 14 individualized compliant elements, each with their own relationship between cross-sectional area and transmural pressure. Conceptually this model is based upon flow limitation induced by the narrowing of duct due to collapsing pressure. For a given inspiratory pressure and for a given compliance distribution, this model predicts the area profile and inspiratory flow. Acoustic rhinometry and posterior rhinomanometry were used to determine the initial geometric area and mechanical characteristics of each element. The proposed model, used under steady-state conditions, is able to simulate the pressure-flow relationship observed in vivo under normal conditions (4 subjects) and under pathological conditions 4 vasomotor rhinitis and 3 valve syndrome subjects). Our results suggest that nasal wall compliance is an essential parameter to understand the nasal inspiratory flow limitation phenomenon and the associated increase of resistance well known to physiologists. By predicting the functional pressure-flow relationship, this model could be a useful tool for the clinician to evaluate the potential effects of treatments.




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J.-F. Papon, L. Brugel-Ribere, R. Fodil, C. Croce, C. Larger, M. Rugina, A. Coste, D. Isabey, F. Zerah-Lancner, and B. Louis
Nasal wall compliance in vasomotor rhinitis
J Appl Physiol, January 1, 2006; 100(1): 107 - 111.
[Abstract] [Full Text] [PDF]


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