| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Articles in PresS, published online ahead of print November 15, 2002
J Appl Physiol, 10.1152/jap.00619.2002
Submitted on July 9, 2002
Accepted on November 13, 2002
1 Department of Physiology and Pharmacology, University of Western Ontario, Lawson Health Research Institute, London, Ontario, Canada
2 Department of Obstetrics and Gynaecology, University of Western Ontario, Lawson Health Research Institute, London, Ontario, Canada
3 Department of Physiology and Pharmacology, University of Western Ontario, Lawson Health Research Institute, London, Ontario, Canada; Department of Medicine, University of Western Ontario, Lawson Health Research Institute, London, Ontario, Canada; Department of Medicine, University of Western Ontario, Lawson Health Research Institute, London, Ontario, Canada
* To whom correspondence should be addressed. E-mail: tbailey2{at}uwo.ca.
Mechanical ventilation (MV) is a necessary intervention for patients with acute lung injury (ALI). However, MV can propagate ALI and increase systemic inflammation. The exposure to greater than 21% oxygen is often associated with MV, yet has not been examined within the context of lung stretch. We hypothesized that mice exposed to >90% oxygen will be more susceptible to the deleterious effects of high stretch MV. C57B1/6 mice were randomized into 48hr exposure of 21% or >90% oxygen, mice were then sacrificed and isolated lungs were randomized into a non-stretch or an ex vivo high stretch MV group. Lungs were assessed for compliance and lavaged for surfactant analysis and cytokine measurements or lungs were homogenized for surfactant associated protein analysis. Mice exposed to >90% + stretch had significantly lower compliance, altered pulmonary surfactant and increased inflammatory cytokines compared to all other groups. Our conclusion is that 48hrs of >90% oxygen and high stretch MV deleteriously affect lung function to a greater degree than stretch alone.
This article has been cited by other articles:
|
|
 |
|
  P. Kopterides, T. Kapetanakis, I. I. Siempos, C. Magkou, A. Pelekanou, T. Tsaganos, E. Giamarellos-Bourboulis, C. Roussos, and A. Armaganidis Short-Term Administration of a High Oxygen Concentration Is Not Injurious in an Ex-Vivo Rabbit Model of Ventilator-Induced Lung Injury Anesth. Analg., February 1, 2009; 108(2): 556 - 564. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. L. Martin, T. A. Sheikh, K. J. Leco, J. F. Lewis, and R. A. W. Veldhuizen Contribution of alveolar macrophages to the response of the TIMP-3 null lung during a septic insult Am J Physiol Lung Cell Mol Physiol, September 1, 2007; 293(3): L779 - L789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. P. Desai, S. E. Sinclair, K. E. Chapman, A. Hassid, and C. M. Waters High tidal volume mechanical ventilation with hyperoxia alters alveolar type II cell adhesion Am J Physiol Lung Cell Mol Physiol, September 1, 2007; 293(3): L769 - L778. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Martin, L. A. McCaig, B. Z. Moyer, M. C. Pape, K. J. Leco, J. F. Lewis, and R. A. W. Veldhuizen Differential response of TIMP-3 null mice to the lung insults of sepsis, mechanical ventilation, and hyperoxia Am J Physiol Lung Cell Mol Physiol, August 1, 2005; 289(2): L244 - L251. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. C. Bailey, K. A. Da Silva, J. F. Lewis, K. Rodriguez-Capote, F. Possmayer, and R. A. W. Veldhuizen Physiological and inflammatory response to instillation of an oxidized surfactant in a rat model of surfactant deficiency J Appl Physiol, May 1, 2004; 96(5): 1674 - 1680. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Martin, B. Z. Moyer, M. C. Pape, B. Starcher, K. J. Leco, and R. A. W. Veldhuizen Negative impact of tissue inhibitor of metalloproteinase-3 null mutation on lung structure and function in response to sepsis Am J Physiol Lung Cell Mol Physiol, December 1, 2003; 285(6): L1222 - L1232. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
