| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Articles in PresS, published online ahead of print October 12, 2001
J Appl Physiol, 10.1152/jap.00616.2001
Submitted on June 14, 2001
Accepted on October 8, 2001
1 Internal Medicine, Section of Gerontology & Geriatrics, Leiden University Medical Center, Leiden, Netherlands
2 Radiology, Leiden University Medical Center, Leiden, Netherlands
3 Neurology, Leiden University Medical Center, Leiden, Netherlands
4 Physiology, Leiden University Medical Center, Leiden, Netherlands
* To whom correspondence should be addressed. E-mail: gerardblauw{at}compuserve.com.
Nitric oxide (NO) plays a pivotal role in the regulation of peripheral vascular tone. It's role in the regulation of cerebral vascular tone in humans remains to be elucidated. This study investigates the role of NO in hypoxia-induced cerebral vasodilatation in young healthy volunteers. The effect of the NO synthase inhibitor L-NMMA on the cerebral blood flow (CBF) was assessed during normoxia (SpO2 97%) and during hypoxia (SpO2 80%). Subjects were positioned in a MR-scanner, breathing normal air (normoxia) or a N2/O2 mixture (hypoxia). The CBF was measured before and after administration of L-NMMA (3 mg/kg) using phase contrast Magnetic Resonance Imaging (pcMRI) techniques. Administration of L-NMMA during normoxia did not affect CBF. Hypoxia increased CBF from 1049 ± 113 to 1209 ± 143 ml/min (P<0.05). After L-NMMA administration, the augmented CBF returned to baseline (1050 ± 161 ml/min; P<0.05). Similarly, cerebral vascular resistance declined during hypoxia, and returned to baseline after administration of L-NMMA (P<0.05 for both). Using pcMRI, it is shown that hypoxia induced cerebral vasodilatation in humans is mediated by NO.
This article has been cited by other articles:
|
|
 |
|
  M. A. Pawlak, J. Krejza, W. Rudzinski, J. L. Kwiatkowski, R. Ichord, A. F. Jawad, M. Tomaszewski, and E. R. Melhem Sickle Cell Disease: Ratio of Blood Flow Velocity of Intracranial to Extracranial Cerebral Arteries--Initial Experience Radiology, May 1, 2009; 251(2): 525 - 534. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Toda, K. Ayajiki, and T. Okamura Cerebral Blood Flow Regulation by Nitric Oxide: Recent Advances Pharmacol. Rev., March 1, 2009; 61(1): 62 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Bailey, K. A. Evans, P. E. James, J. McEneny, I. S. Young, L. Fall, M. Gutowski, E. Kewley, J. M. McCord, K. Moller, et al. Altered free radical metabolism in acute mountain sickness: implications for dynamic cerebral autoregulation and blood-brain barrier function J. Physiol., January 1, 2009; 587(1): 73 - 85. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. C. Peebles, A. M. Richards, L. Celi, K. McGrattan, C. J. Murrell, and P. N. Ainslie Human cerebral arteriovenous vasoactive exchange during alterations in arterial blood gases J Appl Physiol, October 1, 2008; 105(4): 1060 - 1068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ide, M. Worthley, T. Anderson, and M. J. Poulin Effects of the nitric oxide synthase inhibitor L-NMMA on cerebrovascular and cardiovascular responses to hypoxia and hypercapnia in humans J. Physiol., October 1, 2007; 584(1): 321 - 332. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. E. Foster, P. J. Hanly, M. Ostrowski, and M. J. Poulin Effects of Continuous Positive Airway Pressure on Cerebral Vascular Response to Hypoxia in Patients with Obstructive Sleep Apnea Am. J. Respir. Crit. Care Med., April 1, 2007; 175(7): 720 - 725. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. H. ten Dam, F. M.A Box, A. J.M. de Craen, D. M.J. van den Heuvel, E. L.E.M. Bollen, H. M. Murray, M. A. van Buchem, R. G.J. Westendorp, G. Jan Blauw, and on behalf of the PROSPER Study Group Lack of Effect of Pravastatin on Cerebral Blood Flow or Parenchymal Volume Loss in Elderly at Risk for Vascular Disease Stroke, August 1, 2005; 36(8): 1633 - 1636. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Casanello, A. Torres, F. Sanhueza, M. Gonzalez, M. Farias, V. Gallardo, M. Pastor-Anglada, R. S. Martin, and L. Sobrevia Equilibrative Nucleoside Transporter 1 Expression Is Downregulated by Hypoxia in Human Umbilical Vein Endothelium Circ. Res., July 8, 2005; 97(1): 16 - 24. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J Norcliffe, M Rivera-Ch, V. E Claydon, J. P Moore, F Leon-Velarde, O Appenzeller, and R Hainsworth Cerebrovascular responses to hypoxia and hypocapnia in high-altitude dwellers J. Physiol., July 1, 2005; 566(1): 287 - 294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Meadows, D. M. O'Driscoll, A. K. Simonds, M. J. Morrell, and D. R. Corfield Cerebral blood flow response to isocapnic hypoxia during slow-wave sleep and wakefulness J Appl Physiol, October 1, 2004; 97(4): 1343 - 1348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Vasquez, F. Sanhueza, R. Vasquez, M. Gonzalez, R. San Martin, P. Casanello, and L. Sobrevia Role of adenosine transport in gestational diabetes-induced L-arginine transport and nitric oxide synthesis in human umbilical vein endothelium J. Physiol., October 1, 2004; 560(1): 111 - 122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Gonzalez-Alonso, M. K. Dalsgaard, T. Osada, S. Volianitis, E. A. Dawson, C. C. Yoshiga, and N. H. Secher Brain and central haemodynamics and oxygenation during maximal exercise in humans J. Physiol., May 15, 2004; 557(1): 331 - 342. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Zhang, T. E. Wilson, S. Witkowski, J. Cui, C. G. Crandall, and B. D. Levine Inhibition of nitric oxide synthase does not alter dynamic cerebral autoregulation in humans Am J Physiol Heart Circ Physiol, March 1, 2004; 286(3): H863 - H869. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. H. M. van der Helm-van Mil, E. J. W. van Someren, R. van den Boom, M. A. van Buchem, A. J. M. de Craen, and G. J. Blauw No Influence of Melatonin on Cerebral Blood Flow in Humans J. Clin. Endocrinol. Metab., December 1, 2003; 88(12): 5989 - 5994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Toda and T. Okamura The Pharmacology of Nitric Oxide in the Peripheral Nervous System of Blood Vessels Pharmacol. Rev., June 1, 2003; 55(2): 271 - 324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J Hunter, A. B Blood, C. R White, W. J Pearce, and G. G Power Role of nitric oxide in hypoxic cerebral vasodilatation in the ovine fetus J. Physiol., June 1, 2003; 549(2): 625 - 633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Van Lieshout, W. Wieling, J. M. Karemaker, and N. H. Secher Syncope, cerebral perfusion, and oxygenation J Appl Physiol, March 1, 2003; 94(3): 833 - 848. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
