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J Appl Physiol (November 16, 2001). doi:10.1152/japplphysiol.00613.2001
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Articles in PresS, published online ahead of print November 16, 2001
J Appl Physiol, 10.1152/jap.00613.2001
Submitted on June 14, 2001
Accepted on November 9, 2001

Effects of Postnatal Maturation on Energetics and Crossbridge Properties in Rat Diaphragm

Gilles A Orliaguet1*, Olivier Langeron2, Belaid Bouhemad2, Pierre Coriat2, Yves Lecarpentier3, and Bruno Riou4

1 Department of Anesthesiology and Critical Care, Centre Hospitalo-Universitaire Necker-Enfants Malades, Paris, France
2 Department of Anesthesiology and Critical Care, Centre Hospitalo-Universitaire Pitie-Salpetriere, Paris, France
3 Department of Physiology, Centre Hospitalo-Universitaire Bicetre, Le Kremlin-Bicetre, France
4 Department of Emergency Medicine and Surgery, Centre Hospitalo-Universitaire Pitie-Salpetriere, Paris, France

* To whom correspondence should be addressed. E-mail: gilles.orliaguet{at}nck.ap-hop-paris.fr.

The effects of maturation on crossbridge (CB) properties were studied in rat diaphragm strips obtained at postnatal days 3, 10, 17 and in adults (10-12 wk). Calculations of muscle energetics and characteristics of crossbridges (CBs) were determined from the standard Huxley equations. Maturation did not change the curvature G of the force-velocity relationship or the peak of mechanical efficiency. There was a significant increase in the total number of CBs per cross-sectional area (m) with aging, but not in single CB force. The turnover rate of myosin ATPase increased, the duration of the CB cycle decreased, and the velocity of CBs decreased significantly only after the first week postpartum. There was a linear relationship between maximum total force and m (r=0.969, p<0.001), and between maximum unloaded shortening velocity and m (r=0.728, p<0.001). Comparing this study in the rat and previous study in the hamster, it appears that there are few species differences in the postnatal maturation process of the diaphragm.




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