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J Appl Physiol (December 6, 2002). doi:10.1152/japplphysiol.00612.2002
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Articles in PresS, published online ahead of print December 6, 2002
J Appl Physiol, 10.1152/jap.00612.2002
Submitted on July 9, 2002
Accepted on November 26, 2002

Inter- and intraregional ventilation inhomogeneity in hypergravity and after pressurization of an anti-G suit

Mikael Gronkvist1*, Eddie Bergsten1, Ola Eiken2, and Per M Gustafsson3

1 Defence Medicine, Swedish Defence Research Agency, Linkoping, Sweden
2 Defence Medicine, Karolinska Institutet, Swedish Defence Research Agency, Stockholm, Sweden
3 Defence Medicine, Swedish Defence Research Agency, Linkoping, Sweden; Department of Pediatric Clinical Physiology, Queen Silvia Children's Hospital, Goteborg, Sweden

* To whom correspondence should be addressed. E-mail: mikgro{at}foi.se.

This study assessed the effects of increased gravity in the head-to-foot direction (+Gz) and anti-G suit (AGS) pressurization on FRC, the volume of trapped gas (VTG), and ventilation distribution using inert gas washout. Normalized phase III-slope (SnIII) analysis was used to determine the effects on inter- and intraregional ventilation inhomogeneity. Twelve males performed multiple-breath washouts of SF6 and He in a human centrifuge at +1Gz to +3Gz wearing an AGS pressurized to 0, 6, or 12 kPa. Hypergravity produced moderately increased FRC, VTG, overall, and inter- and intraregional inhomogeneities. In normogravity AGS pressurization resulted in reduced FRC and increased VTG, overall, and inter- and intraregional inhomogeneities. Inflation of the AGS to 12 kPa at +3Gz reduced FRC markedly, caused marked gas trapping and intraregional inhomogeneity, while interregional inhomogeneity decreased. In conclusion, increased +Gz impairs ventilation distribution not only between widely separated lung regions, but also within small lung units. Pressurizing an AGS in hypergravity causes extensive gas trapping accompanied by reduced interregional inhomogeneity, and, apparently, results in greater intraregional inhomogeneity.




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