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J Appl Physiol (August 30, 2002). doi:10.1152/japplphysiol.00596.2002
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Articles in PresS, published online ahead of print August 30, 2002
J Appl Physiol, 10.1152/jap.00596.2002
Submitted on July 3, 2002
Accepted on August 28, 2002

Volume dependence of airway and tissue impedances in mice

Peter D Sly1*, Rachel A Collins1, Cindy Thamrin1, Debra J Turner1, and Zoltan Hantos2

1 Division of Clinical Sciences, Telethon Institute for Child Health Research, School of Child Health, University of Western Australia, Perth, Western Australia, Australia
2 Division of Clinical Sciences, Telethon Institute for Child Health Research, School of Child Health, University of Western Australia, Perth, Western Australia, Australia; Department of Medical Informatics and Engineering, University of Szeged, Szeged, Hungary

* To whom correspondence should be addressed. E-mail: peters{at}ichr.uwa.edu.au.

We measured respiratory input impedance (1-25 Hz) in mice and obtained parameters for airway and tissue mechanics by model fitting. Lung volume was varied by inflating to airway opening pressures (Pao) between 0 and 20 cmH2O. The expected pattern of changes in respiratory mechanics with increasing lung volume was seen: a progressive fall in airway resistance and increases in the co-efficients of tissue damping and elastance. A surprising pattern was seen in hysteresivity ({eta}), with a plateau at low lung volumes (Pao < 10 cmH2O), a sharp fall occurring between 10 and 15 cmH2O and {eta} approaching a second (lower) plateau at higher lung volumes. Studies designed to elucidate the mechanism(s) behind this behaviour revealed that this was not due to: chest-wall properties; regional inhomogeneitiesdifferences in volume history at low lung volume; time-dependence of volume recruitment; or surface-acting forces. Our data are consistent with the notion that at low lung volumes the properties mechanics of the tissue matrix determine {eta}, while at high lung volumes the properties of individual fibres (collagen) become more important.




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