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J Appl Physiol (February 9, 2006). doi:10.1152/japplphysiol.00594.2005
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Submitted on May 20, 2005
Accepted on February 6, 2006

DIFFERENCES IN THE TIME COURSE OF PROXIMAL AND DISTAL AIRWAY RESPONSE TO INHALED HISTAMINE STUDIED BY SYNCHROTRON RADIATION CT

Sam Bayat1*, Liisa Porra2, Heikki Suhonen2, Christian Nemoz1, Pekka Suortti2, and Anssi R.A. Sovijarvi3

1 Medical Beamline - ID17, European Synchrotron Radiation Facility, Grenoble, France
2 Department of Physical Sciences, University of Helsinki, Helsinki, Finland
3 Department of Clinical Physiology and Nuclear Medicine, Helsinki University Central Hospital, Helsinki, Finland

* To whom correspondence should be addressed. E-mail: sambayat{at}hotmail.fr.

We studied the kinetics of proximal and distal bronchial response to histamine aerosol in healthy anesthetized and mechanically ventilated rabbits up to 60 min after histamine administration using a novel xenon-enhanced synchrotron radiation CT imaging technique. Individual proximal airway constriction was assessed by measuring the luminal cross-sectional area. Distal airway obstruction was estimated by measuring the ventilated alveolar area following inhaled xenon administration. Respiratory system conductance (G) was assessed continuously. Proximal airway cross-sectional area decreased by 57% of the baseline value by 20 min and recovered gradually but incompletely within 60 min. The ventilated alveolar area decreased immediately after histamine inhalation by 55% of baseline value and recovered rapidly thereafter. The results indicate that the airway reaction to inhaled histamine and the subsequent recovery are significantly slower in proximal than in distal bronchi in healthy rabbit. The findings suggest that physiological reaction mechanisms to inhaled histamine in the airway walls of large and small bronchi are not similar.




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