Journal of Applied Physiology AJP: Regulatory, Integrative and Comparative Physiology
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J Appl Physiol (August 8, 2003). doi:10.1152/japplphysiol.00594.2003
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Submitted on June 10, 2003
Accepted on August 6, 2003

Gender-Specific Effects of Thyroid Hormones on Cardiopulmonary Function in WKY & SHHF Rats

Evelyn H Schlenker1*, T. Tamura2, and A. M. Gerdes2

1 Division of Basic Biomedical Sciences, University of South Dakota School of Medicine, Vermillion, SD, USA
2 Cardiovascular Research Institute, South Dakota Health Research Foundation, Sioux Falls, SD, USA

* To whom correspondence should be addressed. E-mail: eschlenk{at}usd.edu.

Spontaneously hypertensive heart failure (SHHF) rats develop hypertension and heart failure. We hypothesized that inducing hyperthyroidism should accelerate development of heart failure in male SHHF rats. Male and female SHHF and WKY normotensive rats received diets containing desiccated thyroid glands (DTG) or a control diet for 8 weeks. In DTG-treated animals serum thyroid hormone levels were more elevated in WKY than in SHHF rats, while oxygen consumption increased in all rats. DTG treatment reduced body weight in WKY and SHHF males, but not in females of each genotype. Ventilatory equivalents of DTG-treated SHHF male and female rats were lower then in genotype controls, but not in WKY rats. DTG increased heart weights/body weights, heart rates, right ventricular pressures and increased left ventricular pressure in all groups except SHHF males. Thus, WKY rats exhibit a higher sensitivity than male SHHF rats that exhibited an attenuated cardiopulmonary response to DTG possibly indicative of a euthryoid sick syndrome.




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