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J Appl Physiol (August 11, 2005). doi:10.1152/japplphysiol.00590.2005
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Submitted on May 19, 2005
Accepted on August 3, 2005

The effect of exercise, training, and glycogen availability on IL-6 receptor expression in human skeletal muscle

Charlotte Keller1*, Adam Steensberg1, Anne K Hansen1, Christian P Fischer1, Peter Plomgaard1, and Bente Klarlund Pedersen1

1 The Copenhagen Muscle Research Centre/Centre of Inflammation and Metabolism, University Hospital of Copenhagen, Copenhagen, Denmark

* To whom correspondence should be addressed. E-mail: ckeller{at}inflammation-metabolism.dk.

The cytokine interleukin-6 (IL-6) exerts it actions via the IL-6 receptor (IL-6R) in conjunction with the ubiquitously expressed gp130 receptor. IL-6 is tightly regulated in response to exercise, being affected by factors such as exercise intensity and duration, as well as energy availability. Although the IL-6 response to exercise has been extensively studied, little is known about the regulation of the IL-6R response. In the present study we aimed to investigate the effect of exercise, training and glycogen availability, factors known to affect IL-6, on the regulation of the IL-6R gene expression in human skeletal muscle. Human subjects performed either ten weeks of training with an acute exercise bout before and after the training period, or a low glycogen versus normal glycogen acute exercise trial. The IL-6R mRNA response in skeletal muscle and plasma was evaluated in both trials. In response to acute exercise, an increase in IL-6R mRNA levels was observed. Neither training nor intra-muscular glycogen levels had an effect on the IL-6R mRNA response to exercise. However, after ten weeks of training, the skeletal muscle expressed a higher level of IL-6R mRNA compared to before training. The current study demonstrated that the IL-6R gene expression in skeletal muscle is increased in response to exercise, a response that is very well conserved, not being affected by neither training status nor intra-muscular glycogen levels, as opposed to IL-6. However, after the training period, IL-6R mRNA production was increased in skeletal muscle, suggesting a sensitisation of skeletal muscle to IL-6.




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