Journal of Applied Physiology AJP: Cell Physiology
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J Appl Physiol (November 7, 2003). doi:10.1152/japplphysiol.00578.2003
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Submitted on June 4, 2003
Accepted on November 4, 2003

Effects of positive pressure ventilation on the spontaneous baroreflex in healthy subjects

Ingo Fietze1*, Dietrich Romberg2, Martin Glos1, Susanne Endres1, Heinz Theres1, Christian Witt1, and Virend K Somers3

1 Cardiology and Pulmology, Charite - Universitary Medicine Berlin, Berlin, Germany
2 Electrical Engineering, University of Applied Sciences, Koethen, Germany
3 Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA

* To whom correspondence should be addressed. E-mail: ingo.fietze{at}charite.de.

To determine the short-term effects of noninvasive positive pressure ventilation (PPV) on spontaneous baroreflex sensitivity, we acquired time series of RR interval and beat-to-beat blood pressure in 55 healthy volunteers (mean age 46.5±10.5 years) who performed breathing on 4 occasions at a frequency of 12/min and 15/min without positive pressure (control) and also using PPV of 5 mbar. Using spectral and cross spectral analysis, RR interval variability (HRV) and systolic blood pressure variability (SBPV) as well as the gain ({alpha}-index) of the baroreceptor reflex were estimated for the low (LF) and high frequency (HF) bands. Compared to control breathing, PPV at 12/min and 15/min led to an increase in mean RR (p<0.001) and blood pressure (p<0.05). The {alpha}-index of the HF band increased significantly for both respiratory frequencies (p<0.05) due to PPV. These results indicate that short-term administration of PPV in normal subjects elicits a significant enhancement in the high frequency index of the baroreflex gain. These findings may contribute to understanding the mechanisms, indications and effectiveness of positive pressure breathing strategies in treating cardiorespiratory and other disease conditions.




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