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J Appl Physiol (August 9, 2007). doi:10.1152/japplphysiol.00575.2007
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Submitted on May 28, 2007
Accepted on August 6, 2007

PGC-1{beta} is Downregulated by Training in Human Skeletal Muscle: No Effect of Training Twice Every Second Day versus Once Daily on Expression of The PGC-1 Family

Ole Hartvig Mortensen1*, Peter Plomgaard1, Christian Philip Fischer1, Anne K Hansen1, Henriette Pilegaard2, and Bente Klarlund Pedersen1

1 Rigshospitalet, University of Copenhagen, The Centre of Inflammation and Metabolism at Department of Infectious Diseases, Copenhagen, Denmark; Rigshospitalet, University of Copenhagen, Copenhagen Muscle Research Centre, Copenhagen, Denmark
2 Rigshospitalet, University of Copenhagen, Copenhagen Muscle Research Centre, Copenhagen, Denmark; University of Copenhagen, The Centre of Inflammation and Metabolism, Institute of Molecular Biology and Physiology, The August Krogh Institute, Copenhagen, Denmark

* To whom correspondence should be addressed. E-mail: ole{at}hartvig.org.

We hypothesized that the PGC-1 family of transcriptional co-activators (PGC-1{alpha}, PGC-1{beta}, and PRC) is differentially regulated by training once daily vs. training twice daily every second day and that this difference might be observed in the acute response to endurance exercise. Furthermore, we hypothesized that expression levels of the PGC-1 family differ with muscular fiber type composition. Thus, before and after 10 weeks of knee extensor endurance training, training one leg once daily and the other leg twice daily every second day, keeping the total amount of training for the legs equal, skeletal muscle mRNA expression levels of PGC-1{alpha}, PGC-1{beta} and PRC were determined in young healthy men (n=7) in response to 3 hours of acute exercise. No significant difference was found between the two legs, suggesting that regulation of the PGC-1 family is independent of training protocol. Training decreased PGC-1{beta} in both legs, while PGC-1{alpha} was increased, but not significantly in the leg training once daily. PRC did not change with training. Both PGC-1{alpha} and PRC were increased by acute exercise both before and after endurance training, while PGC-1{beta} did not change. The mRNA levels of the PGC-1 family were examined in different types of human skeletal muscle (triceps, soleus and vastus lateralis) (n=7). Only the expression level of PGC-1{beta} differed and correlated inversely with percentage of Type I fibers. In conclusion, there was no difference between training protocols upon the acute exercise and training response of the PGC-1 family, however training caused a decrease in PGC-1{beta} mRNA levels.




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