Journal of Applied Physiology AJP: Regulatory, Integrative and Comparative Physiology
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J Appl Physiol (January 10, 2003). doi:10.1152/japplphysiol.00575.2002
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Submitted on July 1, 2002
Accepted on January 2, 2003

Vascular endothelial growth factor in patients with high-altitude pulmonary edema

Masayuki Hanaoka1*, Yunden Droma1, Atsuhiko Naramoto1, Takayuki Honda2, Toshio Kobayashi1, and Keishi Kubo1

1 First Department of Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
2 Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, Japan

* To whom correspondence should be addressed. E-mail: masayuki{at}hsp.md.shinshu-u.ac.jp.

To examine the role of vascular endothelial growth factor (VEGF) in the pathogenesis of high-altitude pulmonary edema (HAPE), we measured the concentrations of VEGF in venous serum and bronchoalveolar lavage fluid (BALF) in patients with HAPE and healthy volunteers. The VEGF in venous serum of the patients was normal at admission while significantly increased at recovery. Similarly, the VEGF in BALF of the patients was increased at recovery compared to that at admission, but both at admission and recovery were significantly lower than that of the controls, respectively. The present finding suggests that VEGF probably is destroyed in the lung of HAPE and it appears less likely to have a critical part in the pathogenesis of HAPE, but rather an important role in the repair process for the impaired cell layer.




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