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Articles in PresS, published online ahead of print November 27, 2002
J Appl Physiol, 10.1152/jap.00572.2002
Submitted on July 1, 2002
Accepted on November 25, 2002
1 Department of Pharmaceutical Sciences, University of Connecticut Pulmonary Research Consortium, Storrs, CT, USA
2 Department of Medicine, University of Connecticut Health Center, Farmington, CT, USA
3 Department of Pediatrics, University of Connecticut Health Center, Farmington, CT, USA
* To whom correspondence should be addressed. E-mail: morris{at}uconnvm.uconn.edu.
The immediate responses of the upper respiratory tract to the irritants acrolein and acetic acid were examined in healthy and allergic airway diseased C57Bl/6J mouse. Both acrolein (1.1 ppm) and acetic acid vapors (330 ppm) induced an immediate increase in flow resistance as measured in the surgically isolated upper respiratory tract (URT) of urethane-anesthetized healthy animals. Acrolein, but not acetic acid, induced a small URT vasodilatory response. In awake spontaneously breathing mice both vapors induced a prolonged pause at the start of expiration, (a response mediated via stimulation of nasal trigeminal nerves), and an increase in total respiratory specific airway flow resistance, the magnitude of which was similar to that observed in the isolated URT. Both responses were significantly reduced in animals pretreated with large doses of capsaicin to defunctionalize sensory nerves, strongly suggesting a role for sensory nerves in development of these responses. The breathing pattern and/or obstructive responses were enhanced in mice with ovalbumin-induced allergic airway disease. These results suggest that the primary responses to acrolein and acetic acid vapors are altered breathing patterns and airway obstruction, that sensory nerves play an important role in these responses, and that these responses are enhanced in animals with allergic airway disease.
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