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J Appl Physiol (May 24, 2002). doi:10.1152/japplphysiol.00568.2001
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Articles in PresS, published online ahead of print May 24, 2002
J Appl Physiol, 10.1152/jap.00568.2001
Submitted on June 4, 2001
Accepted on May 19, 2002

Gender differences in hepatic gene expression in a rat model of ethanol-induced liver injury

Stasa D Tadic1, Mary S Elm1, Ha-sheng Li2, Gijsberta J VanLonden3, Vladimir M Subbotin4, David C Whitcomb1, and Patricia K Eagon1*

1 Research, Veterans Affairs Medical Center, Pittsburgh, PA, USA; Medicine, University of Pittsburgh, Pittsburgh, PA, USA
2 Medicine, University of Pittsburgh, Pittsburgh, PA, USA
3 Surgery, University of Pittsburgh, Pittsburgh, PA, USA
4 Surgery, University of Pittsburgh, Pittsburgh, PA, USA; Medicine, University of Pittsburgh, Pittsburgh, PA, USA

* To whom correspondence should be addressed. E-mail: pkeagon2{at}pitt.edu.

Gender differences in susceptibility to alcohol-induced liver injury have been observed in both humans and experimental animal models. Using a standard model of alcohol-induced fatty liver injury and microarray analysis, we have identified differential expression of hepatic genes in both sexes. The genes that exhibit differential expression are of three types: those that are changed only in male rats fed alcohol, those that change in only female rats fed alcohol, and those that change in both sexes, although not always in the same manner. Certain of the differentially expressed genes have previously been identified as participants in the induction of alcohol-induced liver injury. However, this analysis has identified a number of genes that heretofore have not been implicated in alcoholic liver injury; such genes may provide new areas of investigation into the pathogenesis of this disease.




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