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1 Clinical Pharmacology Unit & Research Centre, The University of Edinburgh, Edinburgh, Scotland, United Kingdom
2 Department of Pharmacology, University of Dresden, Dresden, Germany
* To whom correspondence should be addressed. E-mail: d.j.webb{at}ed.ac.uk.
Venous occlusion plethysmography is widely used to assess forearm blood flow (FBF). We compared the established Hokanson (HEC4) system with a newly developed Filtrass 2001 (F2001). The HEC4 uses 'mercury-in-silastic' strain gauges while F2001 detects volume changes using a non-mercury linear displacement device. The aim of this study was to evaluate the new F2001 against the HEC4 in terms of repeatability and systematic bias. 10 subjects were studied on 4 separate days in random order using either the HEC4 on both arms (H/H), the F2001 on both arms (F/F), the HEC4 on the right arm with the F2001 on the left (H/F) or the F2001 on the right arm and the HEC4 on the left (F/H). Stroop's coloured word conflict test (SCWT) and post-occlusive hyperaemia were used to increase FBF and lower body negative pressure (LBNP) was used to lower FBF. SCWT and LBNP increased (24.6 ± 1.5%, n = 240, P <0.0001) and decreased (18.7 ± 0.8%, n = 240, P <0.0001) FBF respectively. Post occlusive hyperaemia following occlusion times of 5, 8 and 13 mins substantially increased FBF by 390 ± 86%, 756 ± 217% and 851 ± 132% respectively (All P<0.0001). Repeatability was not different between the devices (0.10 ± 2.37 vs -0.47 ± 1.92 l/min, n = 125, P >0.05) and there was no systematic bias. The F2001 is a newly developed plethysmography system that does not utilise mercury and which is suitable for assessing changes of FBF in physiological studies.
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