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Articles in PresS, published online ahead of print November 27, 2002
J Appl Physiol, 10.1152/jap.00561.2002
Submitted on June 26, 2002
Accepted on November 16, 2002
1 Deparment of Pathology and Biostatistics, University of Liege, Faculty of Veterinary Medicine, Liege, Belgium
* To whom correspondence should be addressed. E-mail: daniel.desmecht{at}ulg.ac.be.
Double chamber plethysmography is recognized since 1979 as a reference technique to measure pulmonary function values (PFV) in guinea pigs, but has not gained attention in mice. Theoretically, however, this technique combines the advantages of single-chamber plethysmography with a quantitative assessment of flow/volume and a calculated resistance the interpretation of which in terms of bronchoconstriction is not disputed. Here, we show that, when appropriately preconditioned, mice are able to gradually grow accustomed to the apparatus and display extremely stable nasal and thoraco-abdominal flow tracings. Overall, strain, sex and somatic growth had a significant effect on PFVs. The changes in specific airway resistance (sRaw) and enhanced pause (Penh) values were never in the same direction, indicating that they measure different things. The respiratory frequency was far higher in C57BL/6 compared to BALB/c. Peak flows, minute volume (MV), specific tidal and minute volumes (sTV and sMV) and sRaw were also higher, but Penh was smaller. Males breathed at a higher frequency than females, leading to a higher MV. Nevertheless, the specific volumes were considerably higher among females. Penh was lower in males, while sRaw was identical in both sexes. Changes associated with somatic growth were rapid and important between 5 and 9 weeks, then slowed down between 9 and 12-13 weeks and became almost imperceptible after.
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