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J Appl Physiol (September 7, 2006). doi:10.1152/japplphysiol.00559.2006
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Submitted on May 17, 2006
Accepted on August 28, 2006

Bicarbonate infusion and pH clamp moderately reduce hyperventilation during ramp exercise in man

Francois R. Peronnet1*, Tim Meyer2, Bernard Aguilaniu3, Carl-Etienne Juneau1, Oliver Faude2, and Wilfried Kindermann2

1 Departement de kinesiologie, Universite de Montreal, Montreal P.Q. H3C 3J7, Canada
2 Institute of Sports and Preventive Medicine, University of Saarland, 66123 Saarbrücken, Germany
3 Laboratoire de physiopathologie de l'exercise, UCP.X, Grenoble, France

* To whom correspondence should be addressed. E-mail: francois.peronnet{at}umontreal.ca.

In order to test the hypothesis that the decrease in plasma pH contributes to the hyperventilation observed in man in response to exercise at high workloads, five healthy male subjects performed a ramp exercise (maximal workload: 352 W [SD 35]) in a control situation and when arterialized plasma pH was maintained at the resting level (pH clamp) by intravenous infusion of sodium bicarbonate (129 mmol [SD 23], beginning at 59 % maximal workload [SD 5]). Bicarbonate infusion did not modify O2 uptake but significantly (P<0.05) increased PaCO2, plasma bicarbonate concentration, and RER (P<0.05). At the three highest workloads VE and VE/VO2 were ~5-10 % lower (P<0.05) when bicarbonate was infused than in the control situation and hyperventilation was reduced by 15-30 %. These data suggest that the decrease in plasma pH is one of the factors which contribute to the hyperventilation observed at high workloads.




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