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1 Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA
2 Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA
3 Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
4 Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA
* To whom correspondence should be addressed. E-mail: byates{at}pitt.edu.
In prior experiments employing the transneuronal transport of isogenic recombinants of pseudorabies virus (PRV), we demonstrated that neurons located ventrally in the medial medullary reticular formation (MRF) of the ferret provide collateralized projections to both diaphragm and abdominal muscle motoneurons as well as to motoneurons innervating multiple abdominal muscles. The goal of the present study was to determine whether single MRF neurons also furnish inputs to diaphragm motoneurons and those innervating an airway muscle with inspiratory-related activity: the tongue protruder genioglossus. For this purpose, PRV recombinants expressing unique reporters (
-galactosidase or enhanced green fluorescent protein) were injected into either the diaphragm or the genioglossal muscle. The virus injections produced transneuronal infection of overlapping populations of MRF neurons. A small proportion of these neurons (<15%) was infected by both PRV recombinants, indicating that they provide collateralized inputs to genioglossal and diaphragm motoneurons. These findings show that whereas some MRF neurons simultaneously influence the activity of upper airway and respiratory pump muscles, other cells in this brainstem region independently contribute to regulating diaphragm and genioglossal muscle contractions.
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