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J Appl Physiol (March 22, 2002). doi:10.1152/japplphysiol.00554.2001
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Articles in PresS, published online ahead of print March 22, 2002
J Appl Physiol, 10.1152/jap.00554.2001
Submitted on June 1, 2001
Accepted on March 14, 2002

Estradiol Increases Salt Intake in Female Normotensive and Hypertensive Rats

Eric Kensicki1, Gail Dunphy1, and Daniel Ely1*

1 Department of Biology, University of Akron, Akron, OH, USA

* To whom correspondence should be addressed. E-mail: Ely1{at}Uakron.edu.

The objective of this study was to examine whether or not estradiol (E2) alters sodium intake in hypertensive and normotensive female rats. It was hypothesized that higher doses of E2 would increase sodium consumption and that this response would be greater in spontaneously hypertensive rats (SHR)s compared to Wistar Kyoto(WKY) rats. The study involved female SHR and WKY (n = 12 per group). All animals were ovariectomized. Six of 12 rats from each strain received three progressively larger doses of beta-estradiol propionate (each dose lasting two weeks) while the other 6 rats from each strain received sham implants. Blood E2 levels were measured by radioimmunoassay after each 2 week period, allowing a 10-day washout period before the next E2 dose. Rats had access to 0.0, 0.5, 1.0, and 1.5% NaCl solutions to drink throughout the experiment. There was a significant positive correlation between sodium intake and plasma E2 (r = 0.8, p < .001). Both strains avoided the 1.5% NaCl and the increased sodium intake was achieved by an increase in consumption of the 0.5% NaCl. SHR females consumed more Na than WKY females which is similar to what has been observed in males of these strains. In conclusion, E2 was positively correlated with sodium intake in both strains of rat, with the hypertensive rats consuming more sodium than the normotensive rats.




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