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J Appl Physiol (October 4, 2002). doi:10.1152/japplphysiol.00547.2002
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Articles in PresS, published online ahead of print October 4, 2002
J Appl Physiol, 10.1152/jap.00547.2002
Submitted on June 25, 2002
Accepted on September 26, 2002

Increased serum nIgM in voluntarily physically active rats: A potential role for B-1 cells

Gwendolyn F Elphick1, Benjamin N Greenwood2, Jay Campisi2, and Monika Fleshner2*

1 Department of Kinesiology and Applied Physiology, Center for Neuroscience, University of Colorado, Boulder, CO, USA;
2 Department of Kinesiology and Applied Physiology, Center for Neuroscience, University of Colorado, Boulder, CO, USA; Center for Neuroscience, University of Colorado, Boulder, CO, USA

* To whom correspondence should be addressed. E-mail: fleshner{at}colorado.edu.

Moderate, habitual physical activity improves health possibly due to beneficial changes in immune function. For example physical activity can increase natural killer cell cytotoxicity, T cell proliferation, and macrophage function, but has minimal impact on antigen-driven B-2 mediated immunologlobulin (Ig) responses. The following studies tested if physical activity selectively impacts nonantigen-driven B-1 natural IgM (nIgM) but not antigen-driven B-2 Ig. Adult male, pathogen-free Sprague-Dawley rats in a barrier facility voluntarily ran in wheels from 7 to 56 days, or were housed in an enriched environment for 56 days. Rats received either no antigen or keyhole limpet hemocyanin (KLH) to assess the B-2 response. Blood samples assessed serum nIgM, total IgG, total serum protein, anti-KLH IgM, and anti-KLH IgG. Physically active rats had higher serum nIgM after 7 days of running, and nIgM remained elevated over 56 days of running. In contrast, freewheel running produced no changes total IgG, total serum protein, anti-KLH IgM, and anti-KLH IgG. Environmental enrichment did not alter immune measures from controls. These results suggest that B-1, and not B-2, cell responses are selectively impacted by physical activity. As nIgM is important in multiple aspects of the immune response, an elevation in this innate humoral component could contribute to improved immunity in physically active organisms.




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