Journal of Applied Physiology Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Appl Physiol (November 16, 2006). doi:10.1152/japplphysiol.00538.2006
This Article
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
102/3/956    most recent
00538.2006v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Arbogast, S.
Right arrow Articles by Reid, M. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Arbogast, S.
Right arrow Articles by Reid, M. B.
Submitted on May 12, 2006
Accepted on October 11, 2006

Bowman-Birk Inhibitor Concentrate Prevents Atrophy, Weakness, and Oxidative Stress in Soleus Muscle of Hindlimb-Unloaded Mice

Sandrine Arbogast1, Jacqueline Smith1, Yves Matuszczak1, Brian Hardin1, Jennifer Moylan1, Jeffrey D Smith1, Jeffrey Ware2, Ann R. Kennedy2, and Michael B. Reid1*

1 Department of Physiology, University of Kentucky Medical Center, Lexington, Kentucky, United States
2 Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States

* To whom correspondence should be addressed. E-mail: michael.reid{at}uky.edu.

Antigravity muscles atrophy and weaken during prolonged mechanical unloading caused by bedrest or space flight. Unloading also induces oxidative stress in muscle, a putative cause of weakness. We tested the hypothesis that dietary supplementation with Bowman-Birk Inhibitor Concentrate (BBIC), a soy protein extract, would oppose these changes. Adult mice were fed a diet supplemented with 1% BBIC during hindlimb unloading for up to 12 d. Relative to controls, soleus muscles weighed less, developed less force per cross-sectional area, and developed less total force after unloading. BBIC supplementation was protective, blunting decrements in soleus weight and force. Cytosolic oxidant activity was assessed using 2,7-dichlorofluorescin diacetate. Oxidant activity increased in unloaded muscle, peaking at day 3 and remaining elevated through day 12. Increases in oxidant activity correlated directly with loss of muscle mass and were abolished by BBIC supplementation. In vitro assays established that BBIC directly buffers reactive oxygen species and also inhibits serine protease activity. We conclude that dietary supplementation with BBIC protects skeletal muscle during prolonged unloading, promoting redox homeostasis in muscle fibers and blunting atrophy-induced weakness.




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
L. Dalla Libera, B. Ravara, V. Gobbo, E. Tarricone, M. Vitadello, G. Biolo, G. Vescovo, and L. Gorza
A transient antioxidant stress response accompanies the onset of disuse atrophy in human skeletal muscle
J Appl Physiol, August 1, 2009; 107(2): 549 - 557.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. M. Siu, E. E. Pistilli, and S. E. Alway
Age-dependent increase in oxidative stress in gastrocnemius muscle with unloading
J Appl Physiol, December 1, 2008; 105(6): 1695 - 1705.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
D. J. Mazzatti, M. A. Smith, R. C. Oita, F.-L. Lim, A. J. White, and M. B. Reid
Muscle unloading-induced metabolic remodeling is associated with acute alterations in PPAR{delta} and UCP-3 expression
Physiol Genomics, July 1, 2008; 34(2): 149 - 161.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
C.-n. Chen, H. M. Brown-Borg, S. G. Rakoczy, and L. V. Thompson
Muscle Disuse: Adaptation of Antioxidant Systems Is Age Dependent
J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2008; 63(5): 461 - 466.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1948 by the American Physiological Society.