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Articles in PresS, published online ahead of print May 3, 2002
J Appl Physiol, 10.1152/jap.00528.2001
Submitted on May 29, 2001
Accepted on May 2, 2002
1 Department of Kinesiology, The University of Western Ontario, School of Kinesiology, London, Ontario, Canada
2 Department of Kinesiology, The University of Western Ontario, School of Kinesiology, London, Ontario, Canada;
* To whom correspondence should be addressed. E-mail: enoble{at}uwo.ca.
Exercise induces expression of the protective heat shock protein, Hsp70, in striated muscle. To characterize the relationship between induction of this protein and exercise intensity in muscles exhibiting different recruitment patterns, male Sprague-Dawley rats were assigned to a sedentary control (Con) or one of 7 exercise groups for which treadmill running speed varied between 15 and 33 m/min (n=8/group). Twenty-four hours after a single 60 min exercise bout, hearts (H), red and white portions of the vastus (RV and WV, respectively), and soleus muscles (SOL) were harvested and analyzed for both relative and absolute Hsp70 content. Cardiac Hsp70 was significantly elevated only when animals were exercised at 24 m/min and beyond. Similarly, Hsp70 was elevated in RV at running speeds above 24 m/min, but did not increase in WV until 27m/min. In contrast, Hsp70 content was initially elevated in the SOL but subsequently declined at the highest running speeds. The observed patterns of Hsp70 expression in skeletal muscle were in general accordance with known muscle recruitment patterns and suggest that alterations in muscle loading, resulting from changes in exercise intensity, are an important component of exercise-induced increases in Hsp70 content.
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