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J Appl Physiol (January 17, 2003). doi:10.1152/japplphysiol.00527.2002
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Submitted on June 18, 2002
Accepted on January 8, 2003

Local particle deposition patterns may play a key role in the development of lung cancer

Imre Blalshazy1*, Werner Hofmann2, and Thomas Heistracher3

1 Radiation and Environmental Physics Department, KFKI Atomic Energy Research Institute, Budapest, Hungary
2 Institute of Physics and Biophysics, University of Salzburg, Salzburg, Austria
3 Department of Informatics and Telematics, Polytechnical University of Salzburg, Salzburg, Austria

* To whom correspondence should be addressed. E-mail: ibalas{at}sunserv.kfki.hu.

The apparent discrepancy between the reported preferential occurrence of bronchial carcinomas in central bronchial airways and current dose estimates for inhaled particles suggests that experimentally observed local accumulations of particles within bronchial airway bifurcations may play a crucial role in lung cancer induction. Here, we computed three-dimensional particle deposition patterns in lobar-segmental airway bifurcations and quantified the resulting inhomogeneous deposition patterns in terms of deposition enhancement factors, which are defined as the ratio of local to average deposition densities. Our results revealed that a small fraction of epithelial cells located at carinal ridges can receive massive doses which may be even a few hundred times higher than the average dose for the whole airway. This lends further credence to the hypothesis that the apparent site selectivity of neoplastic lesions may indeed be caused by the enhanced deposition of toxic particulate matter at bronchial airway bifurcations.




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